Astrocytes in white matter respond to tensile cues during cortical folding: a numerical study.

Karan Taneja, Kengo Saito, Hiroshi Kawasaki, Maria A Holland

Abstract readPreprint

In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Karan TanejaDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0009-0008-8942-6441

Kengo SaitoDepartment of Medical Neuroscience, Graduate School of Medicine Sciences, Kanazawa University, Kanazawa, Ishikawa, 920-8640, Japan.ORCID 0000-0002-4520-3675

Hiroshi KawasakiDepartment of Medical Neuroscience, Graduate School of Medicine Sciences, Kanazawa University, Kanazawa, Ishikawa, 920-8640, Japan.ORCID 0000-0002-2514-1497

Maria A HollandDepartment of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.ORCID 0000-0002-0685-8230

Funding

CRCNS: Defining the role of astrogenesis in cortical foldingR01NS135852 · NINDS · UNIVERSITY OF NOTRE DAME · PI HOLLAND, MARIA · 2023 to 2025

$429k

NINDS NIH HHS R01 NS135852

6 · The paper itself

Abstract

Our understanding of the process of formation of gyri (ridges) and sulci (furrows) in the cerebrum during development is moving beyond the role of neurons. Glial cells such as astrocytes, which are the most common cell type in the brain, are especially prominent under the gyri and have been shown to be essential for gyrification in ferrets. Their dysfunction has been linked to a host of neurodevelopmental diseases and disorders in humans, leading to abnormal folding patterns, hence, it is crucial to understand their role in the mechanics of folding. In this work, we propose two hypotheses of how astrocytes affect cortical folding. Our previous study demonstrated that astrocytes proliferate in the white matter (subcortex), and that inhibiting this process impairs gyrification. This leads to the

Indexed as

AstrocytesCortical foldingFinite Element MethodGrowth

Identifiers

PMID41279345

DOI10.1101/2025.10.17.683172

PMCPMC12633078

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