Evidence map›Paper›PMID 41279309›Full record

ArticlebioRxiv : the preprint server for biology2025

Learning-Dependent Shift from Right to Left CA3 Input Dominance Shapes the Evolution of Right CA1 Spatial Maps.

Anqi Jiang, Douglas GoodSmith, Julliana Ramirez-Matias, Ariana F Tortolani, Mark E J Sheffield

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Anqi JiangUniversity of Chicago.
Douglas GoodSmithUniversity of Chicago.
Julliana Ramirez-MatiasUniversity of Chicago.
Ariana F TortolaniUniversity of Chicago.
Mark E J SheffieldUniversity of Chicago.ORCID 0000-0003-0969-7820

Funding

Sub-cellular resolution functional imaging and optogenetic manipulation of identified memory circuits during behaviorDP2NS111657 · NINDS · UNIVERSITY OF CHICAGO · PI SHEFFIELD, MARK E J · 2018 to 2018
$2.4M
From synapses to neural representations: The role of neuromodulatory circuits in shaping contextual memories in the hippocampusRF1NS127123 · NINDS · UNIVERSITY OF CHICAGO · PI SHEFFIELD, MARK E J · 2022 to 2022
$1.9M
Investigation of a thalamic-hippocampal pathway in contextual fear suppression and extinctionR01MH136274 · NIMH · UNIVERSITY OF CHICAGO · PI Mark E J Sheffield · 2024 to 2026
$1.9M
Encoding properties of bilateral CA3 inputs and their contribution to the formation and dynamics of CA1 spatial representations in novel environmentsR21NS128822 · NINDS · UNIVERSITY OF CHICAGO · PI SHEFFIELD, MARK E J · 2022 to 2022
$436k
NIMH NIH HHS R01 MH136274NINDS NIH HHS DP2 NS111657NINDS NIH HHS R21 NS128822NINDS NIH HHS RF1 NS127123
6 · The paper itself

Abstract

CA1 place fields support spatial maps critical for memory, yet how bilateral CA3 inputs shape these maps during learning remains unclear. Using two-photon calcium imaging and optogenetic inhibition in head-fixed mice navigating a virtual track, we examined left and right CA3 projections to right CA1 (CA1

Identifiers

PMID41279309
PMCPMC12636601

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.