Evidence map›Paper›PMID 41279294›Full record

ArticlebioRxiv : the preprint server for biology2025

Neuronal glycolytic reprogramming drives lethality via accelerated aging in a

Richa Gupta, Hope McGinnis, Elham Rastegari, Matthew S Price, Kartik Venkatachalam

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Richa GuptaDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX, USA.ORCID 0000-0002-1999-1807
Hope McGinnisDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX, USA.
Elham RastegariDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX, USA.ORCID 0000-0001-5264-3743
Matthew S PriceDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX, USA.ORCID 0000-0003-0320-8053
Kartik VenkatachalamDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Sciences Center (UTHealth), Houston, TX, USA.ORCID 0000-0002-3055-9265

Funding

Alterations in synaptic growth and lipid-raft organization in a fly MLIV modelR01NS081301 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VENKATACHALAM, KARTIK · 2014 to 2018
$1.7M
Alterations in somatodendritic bioenergetics in Drosophila models of tauopathyR01AG072176 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARTIK VENKATACHALAM · 2025 to 2026
$766k
Metal responsive transcription factors in neurodegenerationR21AG087381 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VENKATACHALAM, KARTIK · 2025 to 2025
$429k
Neuropathology in tauopathies stem from depolarization-induced alterations in the planar distribution of phosphoinositidesR01AG069076 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI VENKATACHALAM, KARTIK · 2025 to 2025
$383k
NIA NIH HHS R01 AG069076NIA NIH HHS R01 AG072176NIA NIH HHS R21 AG087381NINDS NIH HHS R01 NS081301
6 · The paper itself

Abstract

Neurometabolic dysfunction is a hallmark of Alzheimer's disease (AD) and tauopathies. Whether these changes drive pathology or represent compensatory, protective responses remains unresolved. Here, we demonstrate that human tau induces Warburg-like metabolism in

Identifiers

PMID41279294
PMCPMC12636451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.