ArticlebioRxiv : the preprint server for biology2025
Wnt5a-mediated Adipo-Cardiac Interorgan Communication in HFpEF.
Anam Fatima, Faris Abusharkh, Zoe Zanetta, Sumner Gardner, Fubiao Shi, Elizabeth Kobeck, Niki Fortune, Tuerdi Subati, Katherine N Bachmann, Jonathan D Brown and 8 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
18 authors.
Anam FatimaDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.
Faris AbusharkhDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.
Zoe ZanettaDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.
Sumner GardnerDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.
Fubiao ShiDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.
Elizabeth KobeckDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.
Niki FortuneDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-0172-8672 Katherine N BachmannDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.
Jean W WassenaarDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.ORCID 0000-0002-2835-6338 Sheila CollinsSchool of Medicine, Vanderbilt University, Nashville, TN, USA.
Vineet AgrawalDepartment of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA.ORCID 0000-0002-8457-6722 Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MEffect of PDE5 Inhibition on Adipose Metabolism in HumansR01DK124845 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BRITTAIN, EVAN L, DAMON, BRUCE M. · 2021 to 2025
$3.4M2-HOBA for Treatment of Pulmonary HypertensionR42HL158393 · NHLBI · MTI BIOTECH, INC. · PI RATHMACHER, JOHN A, WEST, JAMES D · 2023 to 2025
$3.1MMentorship in Pulmonary Vascular DiseaseK24HL155891 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Anna R Hemnes · 2022 to 2026
$573kA Pathogenic Role for Natriuretic Peptide Receptor-C in Pulmonary Hypertension and Heart Failure with Preserved Ejection FractionK08HL153956 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI AGRAWAL, VINEET · 2021 to 2022
$317kC-type natriuretic peptide in hypertrophic cardiomyopathyK99HL171847 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARMSTRONG, DAVID WILLIAM JOHN · 2024 to 2025
$261kBLRD VA IK2 BX005828CSRD VA IK2 CX001678NCI NIH HHS P30 CA068485NHLBI NIH HHS K08 HL153956NHLBI NIH HHS K24 HL155891NHLBI NIH HHS K99 HL171847NHLBI NIH HHS R42 HL158393NIDDK NIH HHS R01 DK124845NIDDK NIH HHS U24 DK059637
6 · The paper itselfAbstract
Background: Obesity is an important risk factor in heart failure with preserved ejection fraction (HFpEF), but the precise mechanisms that drive obesity-associated cardiac remodeling are not well understood. Our previous work has shown that increased expression of the natriuretic peptide clearance receptor ( Methods: Results: Global inducible Conclusions: Our study identifies a novel crosstalk mechanism between cardiomyocytes and adipocytes in obesity-associated HFpEF driven by natriuretic peptide-mediated inhibition of release of Wnt5a from adipocytes.
Identifiers
PMID41279279
PMCPMC12636325
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