Evidence map›Paper›PMID 41279276›Full record

ArticlebioRxiv : the preprint server for biology2025

Restoration of Spermatogenesis is Dependent on Activation of a SPRY4-ERK Checkpoint Following Germline Stem Cell Damage.

Ying Liu, Tansol Choi, Brad Pearson, Ryan Nachman, Whitney Woo, Na Xu, Ryan Schreiner, Romulo Hurtado, Marco Seandel, Shahin Rafii and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Ying LiuDepartment of Surgery, Weill Cornell Medicine, New York, NY, USA.
Tansol ChoiDepartment of Surgery, Weill Cornell Medicine, New York, NY, USA.
Brad PearsonDepartment of Surgery, Weill Cornell Medicine, New York, NY, USA.
Ryan NachmanDivision of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Whitney WooNatural Sciences Department, LaGuardia Community College, Long Island City, New York, NY, USA.
Na XuNatural Sciences Department, LaGuardia Community College, Long Island City, New York, NY, USA.
Ryan SchreinerDivision of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Romulo HurtadoDepartment of Surgery, Weill Cornell Medicine, New York, NY, USA.
Marco SeandelDepartment of Surgery, Weill Cornell Medicine, New York, NY, USA.
Shahin RafiiDivision of Regenerative Medicine, Hartman Institute for Therapeutic Organ Regeneration, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Todd R EvansDepartment of Surgery, Weill Cornell Medicine, New York, NY, USA.

Funding

Negative feedback regulation of growth factor signaling in adult spermatogonial stem cellsR01HD101452 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI EVANS, TODD R, LIU, YING · 2021 to 2025
$1.8M
Methods for detection of dynamic intracellular signals in single adult spermatogonial stem cellsR21HD107212 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI EVANS, TODD R, LIU, YING · 2023 to 2024
$463k
NICHD NIH HHS R01 HD101452NICHD NIH HHS R21 HD107212
6 · The paper itself

Abstract

Mammalian spermatogonial stem cells (SSCs) sustain male fertility through continuous self-renewal and differentiation, leading to the production of haploid spermatozoa throughout adulthood. However, SSCs are vulnerable to genotoxic drugs, and patients receiving chemotherapy face a high risk of germline instability and infertility. The molecular mechanisms and cellular pathways that choreograph SSC recovery after chemotherapeutic insult remain unknown. Previously, we identified SPRY4 as an ERK-dependent negative feedback regulator of growth factor signaling that is critical for preservation of stem cell activity in cultured mouse SSCs. Here, we demonstrate that following alkylating agent busulfan (BU)-induced injury, germline-specific

Identifiers

PMID41279276
PMCPMC12632827

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.