Evidence map›Paper›PMID 41279243›Full record

ArticlebioRxiv : the preprint server for biology2025

Spatially patterned cytoskeletal organization shapes astrocyte branch complexity.

Meghan E Wynne, William E Barclay, Dharshini Gopal, Johanna J Bergstrom, Lana T Ho, Eva A Lopez, Eva Nogales, Meng-Meng Fu

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Meghan E WynneDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
William E BarclayNational Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Dharshini GopalDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Johanna J BergstromDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Lana T HoDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Eva A LopezDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Eva NogalesDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.
Meng-Meng FuDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.

Funding

Structural studies of function and regulation of microtubules and transcriptional gene expression machineryR35GM127018 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Eva Nogales · 2018 to 2026
$4.3M
Oligodendrocyte cytoskeletal dynamics and transportZIANS009432 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI FU, MENG MENG · 2021 to 2023
$3.9M
Intramural NIH HHS ZIA NS009432NIGMS NIH HHS R35 GM127018NINDS NIH HHS L40 NS139410
6 · The paper itself

Abstract

Astrocytes, the most abundant cells in the brain, extend elaborate branches that enable diverse functions, from synapse maintenance to blood-brain-barrier integrity. The cytoskeletal basis of this architecture has remained unclear, since traditional culturing methods produce minimal branching. Using immunopanning and serum-free conditions, we generated primary rodent astrocytes with

Identifiers

PMID41279243
PMCPMC12632303

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.