Evidence map›Paper›PMID 41279242›Full record

ArticlebioRxiv : the preprint server for biology2025

The mycobacterial ATP burst is a lysis artifact and serves as an assay for drug-induced cell wall damage.

Claire V Mulholland, Bei Shi Lee, Alexander Chong, Jinhua Cui, Kevin Pethe, Michael Berney

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Claire V MulhollandDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Bei Shi LeeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Alexander ChongDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Jinhua CuiDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Kevin PetheLee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Michael BerneyDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.

Funding

Geographic Medicine and Emerging InfectionsT32AI070117 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WEISS, LOUIS M. · 2008 to 2023
$5.1M
Eradicating persistent M. tuberculosis by synthetic lethality of terminal respiratory oxidasesR01AI139465 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BERNEY, MICHAEL · 2019 to 2023
$3.2M
Identification of new inhibitors of essential functions in M. tuberculosis by high-throughput metabolic profilingR01AI173328 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Michael Berney · 2023 to 2026
$2.6M
The PDIM paradox of M. tuberculosisR01AI175972 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Michael Berney · 2023 to 2026
$2.0M
Coenzyme F420, helping mycobacteria find a niche in humansR21AI159348 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI BERNEY, MICHAEL · 2022 to 2023
$451k
NIAID NIH HHS R01 AI139465NIAID NIH HHS R01 AI173328NIAID NIH HHS R01 AI175972NIAID NIH HHS R21 AI159348NIAID NIH HHS T32 AI070117
6 · The paper itself

Abstract

Antibiotics targeting the mycobacterial cell wall are a cornerstone of tuberculosis treatment. Understanding how these drugs facilitate bacterial killing has important implications for identifying novel therapeutic targets and optimizing drug combinations. Previous studies on mycobacteria using the BacTiter-Glo

Identifiers

PMID41279242
PMCPMC12633423

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.