Evidence map›Paper›PMID 41279233›Full record

ArticlebioRxiv : the preprint server for biology2025

Early cell autonomous and niche-mediated alveolar epithelial response to influenza infection in primary lung organoids.

Amber Elitz, Sharlene Fernandes, Kathleen C S Cook, Helen I Warheit-Niemi, Barbara Zhao, Andrea Toth, Amanda L Zacharias, William J Zacharias

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Amber ElitzMedical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH.
Sharlene FernandesPerinatal Institute, University of Cincinnati College of Medicine, Cincinnati, OH.
Kathleen C S CookPerinatal Institute, University of Cincinnati College of Medicine, Cincinnati, OH.
Helen I Warheit-NiemiPerinatal Institute, University of Cincinnati College of Medicine, Cincinnati, OH.
Barbara ZhaoMedical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH.
Andrea TothMedical Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, OH.
Amanda L ZachariasPerinatal Institute, University of Cincinnati College of Medicine, Cincinnati, OH.ORCID 0000-0002-4818-916X
William J ZachariasPerinatal Institute, University of Cincinnati College of Medicine, Cincinnati, OH.ORCID 0000-0002-2643-0610

Funding

Medical Scientist Training ProgramT32GM063483 · NIGMS · UNIVERSITY OF CINCINNATI · PI KHURANA HERSHEY, GURJIT K. · 2002 to 2022
$6.7M
Pulmonary Development and Disease Pathogenesis Training ProgramT32HL007752 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Francis Xavier McCormack, Anne-Karina Theresia Perl · 1994 to 2026
$6.3M
Dynamic regulatory network models of human response to influenza virusU01AI150748 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI MARAZZI, IVAN, MIRALDI, EMILY · 2020 to 2024
$5.8M
Defining PRC2 complex epigenomic control in alveolar progenitor cellsR01HL166245 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI William John Zacharias · 2023 to 2026
$2.3M
Epigenetic Regulation of the Maturation and Function of Lung Epithelium by the SWI/SNF Proteins ARID1A and ARID1B.R01HL156860 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SINNER, DEBORA, ZACHARIAS, WILLIAM JOHN · 2021 to 2025
$1.9M
Mechanistic evaluation of a novel Wnt-responsive adult alveolar epithelial progenitor population during regeneration after diffuse alveolar damageK08HL140178 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI ZACHARIAS, WILLIAM JOHN · 2018 to 2022
$815k
NHLBI NIH HHS K08 HL140178NHLBI NIH HHS R01 HL156860NHLBI NIH HHS R01 HL166245NHLBI NIH HHS T32 HL007752NIAID NIH HHS U01 AI150748NIGMS NIH HHS T32 GM063483
6 · The paper itself

Abstract

Influenza A virus (IAV) infection is a significant cause of morbidity and mortality for patients worldwide. Alveolar type 2 (AT2) cells are the preferential target of IAV as part of the pathogenesis of viral pneumonia and acute respiratory distress syndrome (ARDS). Early IAV infection of alveolar cells has been challenging to model both

Identifiers

PMID41279233
PMCPMC12633546

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.