Evidence map›Paper›PMID 41279230›Full record

ArticlebioRxiv : the preprint server for biology2025

Vaginal epithelial estrogen receptor α coordinates glycogen deposition, microbial stability, and pH regulation in mice.

Srinivasan Mahalingam, Erin M Carulli, Jiude Mao, Kalli K Stephens, Jeffery A Erickson, Wipawee Winuthayanon

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Srinivasan MahalingamDepartment of Obstetrics, Gynecology and Women's Health, School of Medicine, Columbia, MO 65211 USA.
Erin M CarulliDepartment of Obstetrics, Gynecology and Women's Health, School of Medicine, Columbia, MO 65211 USA.
Jiude MaoDepartment of Obstetrics, Gynecology and Women's Health, School of Medicine, Columbia, MO 65211 USA.ORCID 0000-0003-0594-0571
Kalli K StephensAnimal Sciences Division, University of Missouri-Columbia, Columbia, MO 65211 USA.ORCID 0000-0002-9323-3764
Jeffery A EricksonDepartment of Obstetrics, Gynecology and Women's Health, School of Medicine, Columbia, MO 65211 USA.ORCID 0000-0001-6036-965X
Wipawee WinuthayanonDepartment of Obstetrics, Gynecology and Women's Health, School of Medicine, Columbia, MO 65211 USA.ORCID 0000-0002-5196-8471

Funding

Disruption of semen liquefaction using specific KLK3 inhibitors as a new contraceptiveR01HD108198 · NICHD · WASHINGTON STATE UNIVERSITY · PI MARTIN M. MATZUK, OV D SLAYDEN · 2022 to 2026
$3.7M
The actions of steroid hormones on oviduct functionR01HD097087 · NICHD · WASHINGTON STATE UNIVERSITY · PI WINUTHAYANON, WIPAWEE · 2019 to 2023
$1.7M
NICHD NIH HHS R01 HD097087NICHD NIH HHS R01 HD108198
6 · The paper itself

Abstract

Estrogen plays a central role in regulating the vaginal environment, but the specific contribution of epithelial estrogen receptor α (ESR1) to microbial and biochemical homeostasis has not been fully defined. In our previous work, we showed that epithelial ESR1 is indispensable for estrogen-induced epithelial proliferation, cornification, and MUC1 expression. Here, using mice with conditional deletion of

Indexed as

16s rRNA sequencingconditional knockoutestrogen receptor αpHvaginal epitheliumvaginal microflora

Identifiers

PMID41279230
PMCPMC12636455

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.