Evidence map›Paper›PMID 41279216›Full record

ArticlebioRxiv : the preprint server for biology2025

Dual-Channel Event Microscopy for Ultrafast Biological Imaging.

Ruipeng Guo, Xueli Pan, Qilin Deng, Abrar Ahmed, Qianwan Yang, Joseph Greene, Tongyu Li, Suet Ying Chan, Zhixiong Chen, Guorong Hu and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Ruipeng GuoDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.
Xueli PanDepartment of Pharmacology, Physiology & Biophysics, Boston University, Boston, MA 02118, USA.
Qilin DengDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.
Abrar AhmedDepartment of Pharmacology, Physiology & Biophysics, Boston University, Boston, MA 02118, USA.
Qianwan YangDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.
Joseph GreeneDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.
Tongyu LiDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.
Suet Ying ChanDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.
Zhixiong ChenDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.
Guorong HuDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.
Hui FengDepartment of Pharmacology, Physiology & Biophysics, Boston University, Boston, MA 02118, USA.
Lei TianDepartment of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.ORCID 0000-0002-1316-4456

Funding

Computational Miniature Mesoscope for Cortex-wide, Cellular resolution Ca2+ Imaging in Freely Behaving MiceR01NS126596 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Lei Tian · 2022 to 2026
$2.0M
The Role of DLST in LeukemogenesisR01CA215059 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FENG, HUI · 2018 to 2022
$2.0M
Mechanisms of lmmunosuppression in MYCN-driven NeuroblastomaR01NS140967 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Hui Feng, Derin B Keskin · 2025 to 2026
$1.3M
NCI NIH HHS R01 CA215059NINDS NIH HHS R01 NS126596NINDS NIH HHS R01 NS140967
6 · The paper itself

Abstract

Many fundamental biological processes-spanning immune-tumor interactions, neuronal signaling, and microvascular flow-exhibit fast, multiscale dynamics among diverse cell types within three-dimensional tissue environments. Capturing such activity requires imaging systems that simultaneously achieve high temporal resolution, multicolor capability, and volumetric coverage over large fields of view (FOVs). However, existing modalities remain limited by tradeoffs among imaging speed, spectral capacity, depth of field (DOF), and spatial resolution. Here, we present Dual-Channel Event Microscopy (DEM), which integrates digital micromirror device (DMD)-based pulsed illumination, extended-DOF optics, and event-based sensing for ultrafast, dual-channel volumetric imaging across a 2.3 × 1.3 mm

Identifiers

PMID41279216
PMCPMC12636556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.