Evidence map›Paper›PMID 41279192›Full record

ArticlebioRxiv : the preprint server for biology2025

VadK, a Non-Canonical Kinase that Regulates the Methylcitrate Cycle and is Essential for

Jordan Pascoe, Jane Newcombe, Jessica Mendoza, Shalini Birua, Tom A Mendum, Kushi Anand, Albel Singh, Amitava Sinha, Kadamba Papavinasasundaram, Apoorva Bhatt and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Jordan PascoeDepartment of Microbial and Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.
Jane NewcombeDepartment of Microbial and Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.
Jessica MendozaDepartment of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA 92697, US.
Shalini BiruaDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka 560012, India.
Tom A MendumDepartment of Microbial and Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.
Kushi AnandDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka 560012, India.
Albel SinghSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Amitava SinhaDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka 560012, India.
Kadamba PapavinasasundaramDepartment of Microbiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, US.
Apoorva BhattSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.ORCID 0000-0002-6655-1636
Gerald Larrouy-MaumusCentre for Bacterial Resistance Biology, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, SW7 2AZ, UK.
Amit SinghDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka 560012, India.ORCID 0000-0001-6761-1664
Celia W GouldingDepartment of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA 92697, US.
Dany Jv BesteDepartment of Microbial and Cellular Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.ORCID 0000-0001-6579-1366

Funding

Vulnerabilities in Mycobacterial Cell-Wall BiogenesisP01AI095208 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SASSETTI, CHRISTOPHER M · 2012 to 2022
$19.8M
T32 for Training in Microbiology & Infectious DiseasesT32AI141346 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Celia Goulding, Melissa Bruckner Lodoen · 2019 to 2026
$1.0M
NIAID NIH HHS P01 AI095208NIAID NIH HHS T32 AI141346
6 · The paper itself

Abstract

The evolution of new enzymatic functions is constrained and guided by the architecture of an organism's metabolic and regulatory networks as well as by environmental constraints. Here, we identify a previously uncharacterized kinase that has evolved from pyruvate phosphate dikinase (PPDK). Through biochemical and systems-level analyses, we show that this enzyme, encoded by Rv1127c in

Identifiers

PMID41279192
PMCPMC12636432

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.