Evidence map›Paper›PMID 41279172›Full record

ArticlebioRxiv : the preprint server for biology2025

Impaired IFNγ responsiveness of monocyte-derived lung cells limits immunity to

Weihao Zheng, Jason D Limberis, Zachary P Howard, Alex Mohapatra, Enzo Takagi, Joel D Ernst

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Weihao ZhengDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, California, USA.ORCID 0000-0002-8038-1207
Jason D LimberisDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, California, USA.ORCID 0000-0002-7893-8416
Zachary P HowardDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, California, USA.ORCID 0000-0002-1958-4638
Alex MohapatraDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, California, USA.ORCID 0000-0003-0400-6146
Enzo TakagiDivision of Nephrology, Department of Medicine, University of California, San Francisco, California, USA.
Joel D ErnstDivision of Experimental Medicine, Department of Medicine, University of California, San Francisco, California, USA.ORCID 0000-0001-9951-6207

Funding

MUTIDISCIPLINARY TRAINING PROGRAM IN LUNG DISEASEST32HL007185 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI David J Erle, LAURENCE HUANG · 1985 to 2026
$24.6M
Initiation of the Immune Response to M. tuberculosisR01AI051242 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ERNST, JOEL D. · 2002 to 2019
$8.3M
Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5M
Functional dynamics of TB granuloma architecture - Diversity Supplement for Kelley J. MartinezU01AI166309 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joel D. Ernst · 2022 to 2026
$3.2M
Tuberculosis Research and Mentorship Program (TB RAMP II)R25AI147375 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Elizabeth Fair, PAYAM NAHID · 2020 to 2026
$2.8M
Mechanistic investigation of differential T cell responses to distinct Mycobacterium tuberculosis antigensF31AI172360 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HOWARD, ZACHARY · 2022 to 2024
$132k
Impact of Mycobacterium tuberculosis on monocyte differentiation in vivoF32HL162424 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOHAPATRA, ALEXANDER · 2023 to 2023
$81k
NHLBI NIH HHS F32 HL162424NHLBI NIH HHS T32 HL007185NIAID NIH HHS F31 AI172360NIAID NIH HHS R01 AI051242NIAID NIH HHS R25 AI147375NIAID NIH HHS T32 AI060537NIAID NIH HHS U01 AI166309
6 · The paper itself

Abstract

Lung mononuclear phagocyte (MNP) subsets differ in their ability to restrict

Identifiers

PMID41279172
PMCPMC12632307

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.