Evidence map›Paper›PMID 41279162›Full record

ArticlebioRxiv : the preprint server for biology2025

Lysosomal permeabilization by Group A

Ava Quezada, Kevin Lord, Cheldon Alcantara, Claire Delahunty, Kevin Kim, Olivia Okamoto, John R Yates, Cheryl Ym Okumura

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ava QuezadaBiology Department, Occidental College, Los Angeles, CA, 90041 USA.
Kevin LordBiology Department, Occidental College, Los Angeles, CA, 90041 USA.
Cheldon AlcantaraBiology Department, Occidental College, Los Angeles, CA, 90041 USA.
Claire DelahuntyDepartment of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
Kevin KimBiology Department, Occidental College, Los Angeles, CA, 90041 USA.
Olivia OkamotoBiology Department, Occidental College, Los Angeles, CA, 90041 USA.
John R YatesDepartment of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.
Cheryl Ym OkumuraBiology Department, Occidental College, Los Angeles, CA, 90041 USA.ORCID 0000-0001-9746-6410

Funding

Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI AMANDA J ROBERTS · 2003 to 2026
$46.3M
TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI DAVIS, TRISHA N. · 2012 to 2021
$20.7M
Macrophage Second-line Responses to Group A Streptoccocus InfectionR15AI176429 · NIAID · OCCIDENTAL COLLEGE · PI OKUMURA, CHERYL YM · 2024 to 2024
$398k
NIAAA NIH HHS P60 AA006420NIAID NIH HHS R15 AI176429NIGMS NIH HHS P41 GM103533
6 · The paper itself

Abstract

The human-specific bacterial pathogen Group A

Indexed as

Group A StreptococcushistonesIL-1βinflammasomelysosomemacrophagestreptolysin O (SLO)

Identifiers

PMID41279162
PMCPMC12633395

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.