Evidence map›Paper›PMID 41279151›Full record

ArticlebioRxiv : the preprint server for biology2025

Atomistic TCR-ligand interactions instruct memory T-cell differentiation.

Aoi Akitsu, Kemin Tan, Robert J Mallis, Matthew A Booker, Jonathan S Duke-Cohan, Kristine N Brazin, Evan H Kirkpatrick, Andrew N Parkins, Sarita Aryal, Vincenzo Cinella and 10 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Aoi AkitsuLaboratory of Immunobiology, Dana-Farber Cancer Institute; Boston, MA 02115, USA.ORCID 0000-0001-7672-9664
Kemin TanStructural Biology Center, X-Ray Science Division, Advanced Photon Source, Argonne National Laboratory; Lemont, IL 60439, USA.ORCID 0000-0002-4003-7903
Robert J MallisLaboratory of Immunobiology, Dana-Farber Cancer Institute; Boston, MA 02115, USA.ORCID 0000-0002-2087-9468
Matthew A BookerDepartment of Informatics and Analytics, Dana-Farber Cancer Institute; Boston, MA 02115, USA.ORCID 0000-0002-6902-1032
Jonathan S Duke-CohanLaboratory of Immunobiology, Dana-Farber Cancer Institute; Boston, MA 02115, USA.ORCID 0000-0002-9478-9609
Kristine N BrazinLaboratory of Immunobiology, Dana-Farber Cancer Institute; Boston, MA 02115, USA.ORCID 0000-0002-4406-9179
Evan H KirkpatrickDepartment of Chemical and Biomolecular Engineering, Vanderbilt University; Nashville, TN 37212, USA.ORCID 0009-0005-3439-4874
Andrew N ParkinsLaboratory of Immunobiology, Dana-Farber Cancer Institute; Boston, MA 02115, USA.ORCID 0000-0003-2821-1398
Sarita AryalLaboratory of Immunobiology, Dana-Farber Cancer Institute; Boston, MA 02115, USA.ORCID 0000-0002-5502-4363
Vincenzo CinellaLaboratory of Immunobiology, Dana-Farber Cancer Institute; Boston, MA 02115, USA.ORCID 0009-0002-8555-2906
Jonathan J LeeLaboratory of Immunobiology, Dana-Farber Cancer Institute; Boston, MA 02115, USA.
Kaveri I UberoyLaboratory of Immunobiology, Dana-Farber Cancer Institute; Boston, MA 02115, USA.ORCID 0009-0001-2858-9211
Jenna K KoenigLaboratory of Immunobiology, Dana-Farber Cancer Institute; Boston, MA 02115, USA.ORCID 0000-0001-6952-955X
Matthew BiddleLaboratory of Immunobiology, Dana-Farber Cancer Institute; Boston, MA 02115, USA.
Cameron M MessierBelfer Center for Applied Cancer Science, Dana-Farber Cancer Institute; Boston, MA, USA.ORCID 0000-0002-2718-6525
Patrick H LizotteBelfer Center for Applied Cancer Science, Dana-Farber Cancer Institute; Boston, MA, USA.ORCID 0000-0001-9510-0036
Michael Y TolstorukovDepartment of Informatics and Analytics, Dana-Farber Cancer Institute; Boston, MA 02115, USA.ORCID 0000-0002-9134-8808
Wonmuk HwangDepartments of Biomedical Engineering, Materials Science & Engineering, Physics & Astronomy, Texas A&M University; College Station, TX 77843, USA.ORCID 0000-0001-7514-3186
Matthew J LangDepartment of Chemical and Biomolecular Engineering, Vanderbilt University; Nashville, TN 37212, USA.
Ellis L ReinherzLaboratory of Immunobiology, Dana-Farber Cancer Institute; Boston, MA 02115, USA.ORCID 0000-0003-1048-5526

Funding

Protein Production CoreP01AI143565 · NIAID · DANA-FARBER CANCER INST · PI Matthew J. Lang, ELLIS L REINHERZ · 2020 to 2026
$19.9M
NIAID NIH HHS P01 AI143565
6 · The paper itself

Abstract

Memory T cells endow the mammalian host with an essential form of adaptive immunity that generates durable and rapid protection following re-exposure to an infectious pathogen or a cancerous transformation

Identifiers

PMID41279151
PMCPMC12637697

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.