Evidence map›Paper›PMID 41279126›Full record

ArticlebioRxiv : the preprint server for biology2025

A Fkh1/2 binding site array in the

Jacob Kim, Shicong Xie, Lucas Fuentes Valenzuela, Jordan Xiao, Mike C Lanz, Xin Gao, Matthew Swaffer, Corbin E Mitchell, Seth M Rubin, Kurt Schmoller and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jacob KimDepartment of Biology, Stanford University, Stanford CA, USA.ORCID 0000-0002-9306-4446
Shicong XieDepartment of Biology, Stanford University, Stanford CA, USA.ORCID 0000-0002-3283-3248
Lucas Fuentes ValenzuelaDepartment of Biology, Stanford University, Stanford CA, USA.
Jordan XiaoDepartment of Biology, Stanford University, Stanford CA, USA.
Mike C LanzDepartment of Biology, Stanford University, Stanford CA, USA.ORCID 0000-0001-8175-7627
Xin GaoDepartment of Biology, Stanford University, Stanford CA, USA.
Matthew SwafferDepartment of Biology, Stanford University, Stanford CA, USA.
Corbin E MitchellDepartment of Chemistry and Biochemistry, University of California, Santa Cruz CA, USA.
Seth M RubinDepartment of Chemistry and Biochemistry, University of California, Santa Cruz CA, USA.
Kurt SchmollerInstitute of Functional Epigenetics, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Neuherberg, Germany.
Jan M SkotheimDepartment of Biology, Stanford University, Stanford CA, USA.

Funding

Determining how cell growth triggers cell divisionR35GM134858 · NIGMS · STANFORD UNIVERSITY · PI Jan M Skotheim · 2020 to 2026
$4.1M
Molecular Mechanisms of Cell Cycle Dependent Gene ExpressionR35GM145255 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI Seth Michael Rubin · 2022 to 2026
$3.0M
Molecular Pharmacology Training ProgramT32GM136631 · NIGMS · STANFORD UNIVERSITY · PI BOGYO, MATTHEW, CHEN, JAMES K · 2021 to 2025
$2.0M
NIGMS NIH HHS R35 GM134858NIGMS NIH HHS R35 GM145255NIGMS NIH HHS T32 GM136631
6 · The paper itself

Abstract

Cells typically regulate their size within a relatively tight range by coupling growth to the cell division cycle using a dedicated set of molecular mechanisms. In budding yeast, cells are born with a similar amount of the G1/S inhibitor protein Whi5 that is then diluted by growth throughout G1. As cells grow, Whi5 concentration decreases and cells become more likely to enter the cell cycle. Cells are born in G1 with similar amounts of Whi5 because of the size-independent (sub-scaling) expression of

Identifiers

PMID41279126
PMCPMC12632407

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.