Evidence map›Paper›PMID 41279119›Full record

ArticlebioRxiv : the preprint server for biology2025

Timing of immune checkpoint blockade shapes anti-tumor immunity via a clock-dependent chemokine axis.

Jake N Lichterman, Tarun Srinivasan, Ruheng Wang, Chaitanya Dende, Christina Zarek, Josue I Ramirez, Noheon Park, Hesuiyuan Wang, Wenling Li, Jiwoong Kim and 13 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. CX3CR1 identifies a potent effector CD8Frontiers in immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Jake N LichtermanDepartment of Internal Medicine, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.ORCID 0000-0002-3428-1555
Tarun SrinivasanDepartment of Immunology, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Ruheng WangDepartment of Public Health, O'Donnell School of Public Health, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Chaitanya DendeDepartment of Immunology, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Christina ZarekDepartment of Pediatrics, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Josue I RamirezHarold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Noheon ParkDepartment of Neuroscience, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Hesuiyuan WangDepartment of Pediatrics, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Wenling LiDepartment of Pediatrics, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Jiwoong KimDepartment of Public Health, O'Donnell School of Public Health, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Laura CoughlinDepartment of Pediatrics, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Nicole PoulidesDepartment of Pediatrics, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Parastoo SabaeifardDepartment of Pediatrics, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Suzette N PalmerDepartment of Public Health, O'Donnell School of Public Health, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Aidan C MorrillDepartment of Pediatrics, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Brian HassellDepartment of Immunology, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
John M SheltonHarold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Xin V LiDepartment of Immunology, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Bret M EversDepartment of Pathology, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Xiaowei ZhanDepartment of Public Health, O'Donnell School of Public Health, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Joseph S TakahashiDepartment of Neuroscience, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.
Lora V HooperDepartment of Immunology, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.ORCID 0000-0002-2759-4641
Andrew Y KohDepartment of Pediatrics, University of Texas Southwestern Medical Center; Dallas, TX, 75390, USA.ORCID 0000-0003-2172-5126

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MELANIE H. COBB · 2010 to 2026
$53.7M
Understanding the molecular mechanisms regulating fungal colonization and disease in the mammalian intestinal nicheP01AI179406 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI TOBIAS M HOHL · 2024 to 2026
$9.9M
Microbial Regulation of Retinol Transport and its Role in Intestinal ImmunityR01DK070855 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI LORA V HOOPER · 2005 to 2026
$7.9M
INTEGRATIVE IMMUNOLOGY TRAINING PROGRAMT32AI005284 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Nan Yan · 2003 to 2026
$7.4M
Role of Gut Microbiota in Modulating Immune Checkpoint Inhibitory Therapy for CancerR01CA231303 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HOMSI, JADE, KOH, ANDREW · 2019 to 2023
$3.1M
Investigating the role of a novel fungal RNA in intestinal innate immunity and inflammationDP2AI192036 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Xin Li · 2025 to 2026
$996k
Mechanistic Investigation of Gut Mycobiota in the Regulation of Lung Immunity and DiseaseR00HL157691 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI LI, XIN · 2023 to 2025
$747k
Mentoring Patient Oriented Research in the Microbiome of Cancer and Stem Cell Transplant PatientsK24AI150992 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI KOH, ANDREW · 2020 to 2024
$592k
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA142543NCI NIH HHS R01 CA231303NHLBI NIH HHS R00 HL157691NIAID NIH HHS DP2 AI192036NIAID NIH HHS K24 AI150992NIAID NIH HHS P01 AI179406NIAID NIH HHS T32 AI005284NIDDK NIH HHS R01 DK070855
6 · The paper itself

Abstract

Circadian clocks regulate immunity, yet how they shape the tumor immune microenvironment and influence cancer immunotherapy remains unclear. Here, we show that tumor immune infiltration and immune checkpoint inhibitor efficacy vary by time of day in mice, driven by intrinsic clocks in dendritic cells and CD8

Identifiers

PMID41279119
PMCPMC12637477

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.