ArticlebioRxiv : the preprint server for biology2025
Synergistic effects of deleting the tyrosine phosphatases Shp1 and Shp2 on megakaryopoiesis and thrombopoiesis in mice.
Elsa Barré, Marc-Damien Lourenco-Rodrigues, Lucie Zimmermann, Marion Pugliano, Cécile Loubière, Fabienne Proamer, Jean-Yves Rinckel, Anita Eckly, Zihan Qu, Jinmin Miao and 3 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Elsa BarréInstitut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche - S 1255, Etablissement Français du Sang Grand Est, Université de Strasbourg, Strasbourg, France.ORCID 0009-0000-5056-1349 Marc-Damien Lourenco-RodriguesInstitut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche - S 1255, Etablissement Français du Sang Grand Est, Université de Strasbourg, Strasbourg, France.ORCID 0000-0001-6572-1798 Lucie ZimmermannInstitut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche - S 1255, Etablissement Français du Sang Grand Est, Université de Strasbourg, Strasbourg, France.
Marion PuglianoInstitut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche - S 1255, Etablissement Français du Sang Grand Est, Université de Strasbourg, Strasbourg, France.
Cécile LoubièreInstitut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche - S 1255, Etablissement Français du Sang Grand Est, Université de Strasbourg, Strasbourg, France.
Fabienne ProamerInstitut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche - S 1255, Etablissement Français du Sang Grand Est, Université de Strasbourg, Strasbourg, France.
Jean-Yves RinckelInstitut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche - S 1255, Etablissement Français du Sang Grand Est, Université de Strasbourg, Strasbourg, France.
Anita EcklyInstitut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche - S 1255, Etablissement Français du Sang Grand Est, Université de Strasbourg, Strasbourg, France.ORCID 0000-0001-9620-4961 Zihan QuJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.ORCID 0009-0004-8446-8459 Jinmin MiaoBorch Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0001-7471-0847 Zhong-Yin ZhangJames Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0001-5527-7910 Yotis A SenisInstitut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche - S 1255, Etablissement Français du Sang Grand Est, Université de Strasbourg, Strasbourg, France.ORCID 0000-0002-0947-9957 Alexandra MazharianInstitut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche - S 1255, Etablissement Français du Sang Grand Est, Université de Strasbourg, Strasbourg, France.ORCID 0000-0002-0204-3325 Funding
Papillomavirus TransformationR01CA069292 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI VANDE POL, SCOTT BRIAN · 2002 to 2006
$1.4MNCI NIH HHS R01 CA069292
6 · The paper itselfAbstract
The Src homology 2 (SH2) domain-containing non-transmembrane protein-tyrosine phosphatases 1 and 2 (Shp1 and Shp2) have been implicated in regulating signaling from a variety of receptors and cell types, including the thrombopoietin (Tpo) receptor Mpl in megakaryocytes (MKs) and platelets. We previously showed that deletion of Shp1 and Shp2 in the MK/platelet lineage in mice using the
Indexed as
megakaryopoiesisMpl signalingShp1Shp2thrombopoiesis
Identifiers
PMID41279089
PMCPMC12633275
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