Evidence map›Paper›PMID 41279060›Full record

ArticlebioRxiv : the preprint server for biology2025

DHHC21 is a STIM1 protein S-acyltransferase that modulates immune function

Goutham Kodakandla, Ying Fan, Michael X Zhu, Savannah J West, Askar Akimzhanov, Darren Boehning

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Goutham KodakandlaDepartment of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, USA, 08103.
Ying FanDepartment of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, USA, 08103.
Michael X ZhuDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Sciences Center at Houston, Houston, Texas, 77030.
Savannah J WestDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Sciences Center at Houston, Houston, Texas, 77030.
Askar AkimzhanovDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Sciences Center at Houston, Houston, Texas, 77030.
Darren BoehningDepartment of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, USA, 08103.ORCID 0000-0001-7920-6922

Funding

Regulation of Calcium Signaling by Protein LipidationR01GM130840 · NIGMS · ROWAN UNIVERSITY · PI AKIMZHANOV, ASKAR, BOEHNING, DARREN F · 2019 to 2022
$1.3M
NIGMS NIH HHS R01 GM130840
6 · The paper itself

Abstract

Depletion of calcium from ER stores leads to the activation of calcium channels on the plasma membrane. This process is termed store-operated calcium entry (SOCE). The proteins STIM1 and STIM2 function as ER calcium sensors, and upon store depletion, they undergo a conformational change that allows them to bind to and gate Orai calcium channels on the plasma membrane. We have shown that both Orai1 and STIM1 are dynamically S-acylated after store depletion, which is required for SOCE. These results suggest the requirement of a calcium-activated protein S-acyltransferase such as DHHC21. Here, we show that DHHC21 is essential for SOCE

Identifiers

PMID41279060
PMCPMC12632593

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.