ArticlebioRxiv : the preprint server for biology2025
Profiles of Neuroaffective Responding to Natural Reward-Predicting Cues and Alcohol Images in Alcohol Use Disorder: An Event-Related Potential Approach.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
aimsIncentive salience attribution (ISA) is the process by which the cues associated with reward take on value themselves. Individual differences in ISA are known to predict reward seeking and consuming behavior in animals and humans, suggesting prognostic potential in use disorders like alcohol use disorder (AUD). Since AUD etiology is thought to involve changes in natural (e.g., food) reward processing as much as alcohol-related processing, current research tested if differences in natural reward cue ISA are apparent, and predictive of behavior, in AUD.
methods30 individuals meeting AUD criteria and reporting heavy alcohol consumption on timeline follow-back (TLFB) participated. Subjects completed a validated ISA task wherein pictures depicting inherently appetitive, aversive, or emotionally neutral content are shown along with pictures that are less evocative but are predictive of reward (candy) delivery and (in this study) also alcohol images. To capture individual variations in ISA, a picture-elicited neural response that scales with picture salience - the late positive potential (LPP) - is indexed and then submitted to
resultsReplicating prior work, clustering indicated a 2-group solution where an "F>P" (n=14) group showed
conclusionsSimilarly sized groups of individuals who were more versus less responsive to natural reward cues is consistent with prior studies in non-AUD samples. At the same time, the lack of commensurate differences in task reward consumption differs from those studies, and could reflect change in natural reward processing in individuals with AUD. Implications for continued research are discussed.
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