Evidence map›Paper›PMID 41278997›Full record

ArticlebioRxiv : the preprint server for biology2025

Clinical Interventions and Inflammatory Signaling Shape the Transcriptional and Cellular Architecture of the Early Postnatal Lung.

Tristan Frum, Angeline Wu, Marcela S Ymayo, Yu-Hwai Tsai, Sha Huang, Mengkun Yang, Sydney G Clark, Peggy P Hsu, Ian A Glass, Gail H Deutsch and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tristan FrumDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0003-3452-8762
Angeline WuDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Marcela S YmayoDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0009-0009-8278-2651
Yu-Hwai TsaiDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Sha HuangDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI, USA.
Mengkun YangDepartment of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0003-1780-1210
Sydney G ClarkDepartment of Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0009-0002-7640-483X
Peggy P HsuDepartment of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, MI, USA.
Ian A GlassDepartment of Pediatrics, Genetic Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6762-8407
Gail H DeutschCenter for Respiratory Biology and Therapeutics, Seattle Children's Research Institute, Seattle, WA, USA.ORCID 0000-0002-0571-0285
Jason R SpenceDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0001-7869-3992

Funding

LABORATORY OF DEVELOPMENTAL BIOLOGYR24HD000836 · NICHD · UNIVERSITY OF WASHINGTON · PI Ian Amos Glass · 1995 to 2026
$16.9M
Supplement to a Hox-Wnt-Sox signaling axis regulates lung development, patterning and branchingR01HL119215 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPENCE, JASON · 2013 to 2021
$4.2M
Functional interrogation of a novel SCGB3A2+/SFTPB+ cell in the human airwayR01HL166139 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason Spence · 2023 to 2026
$2.4M
Modeling and characterizing early ALK-dependent lung tumorigenesisK08CA286759 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Peggy Ping Hsu · 2025 to 2026
$325k
NCI NIH HHS K08 CA286759NHLBI NIH HHS R01 HL119215NHLBI NIH HHS R01 HL166139NICHD NIH HHS R24 HD000836
6 · The paper itself

Abstract

The early postnatal period in human development is characterized by extensive remodeling of the distal lung to support gas exchange, but this critical period remains poorly understood. Here, we constructed a comprehensive cellular atlas of the early postnatal human lung (0 to 2 years) using single-nucleus RNA sequencing of histologically normal specimens from 23 individuals. Our analysis identified two previously unknown and mutually exclusive transcriptional states of alveolar type 2 (AT2) cells, one defined by upregulation of genes involved in lipid metabolism and identified by unique expression of

Identifiers

PMID41278997
PMCPMC12633012

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.