In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
10 authors.
Murugesh PadmanarayanaDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.
Saira SakalasDivisions of Structural Biology and Cell and Molecular Biology, The Institute of Cancer Research, London, UK.
Parijat SarkarDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-9435-5600 Mengxiao MaDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-4166-6004 Ethan R GarvinDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-3609-6457 Ethan LeeDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
Steven M CorselloDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-9929-3709 Sebastian GuettlerDivisions of Structural Biology and Cell and Molecular Biology, The Institute of Cancer Research, London, UK.ORCID 0000-0002-3135-1546 Ganesh V PusapatiDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-1406-2566 Rajat RohatgiDepartment of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-7609-8858 Funding
INSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2MVanderbilt-Ingram Cancer Center SPORE in Gastrointestinal CancerP50CA236733 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Robert J. Coffey · 2019 to 2026
$19.6MSupplement application for an Olympus automated microscopeR35GM118082 · NIGMS · STANFORD UNIVERSITY · PI RAJAT ROHATGI · 2016 to 2026
$7.6MMechanism of Wnt signal transductionR35GM122516 · NIGMS · VANDERBILT UNIVERSITY · PI ETHAN LEE · 2017 to 2026
$5.8MInhibition of the Wnt Receptor Complex by the Tumor Suppressor Adenomatous Polyposis ColiR01CA244188 · NCI · DARTMOUTH COLLEGE · PI AHMED, YASMATH, LEE, ETHAN · 2020 to 2024
$3.2MA Cereblon signaling network in Wnt-driven cancersR01CA281002 · NCI · DARTMOUTH COLLEGE · PI Yasmath Ahmed, ETHAN LEE · 2023 to 2026
$2.6MTargeting casein kinase 1-alpha for cancer therapyK08CA230220 · NCI · STANFORD UNIVERSITY · PI CORSELLO, STEVEN MUNTEAN · 2018 to 2022
$1.0MNCI NIH HHS K08 CA230220NCI NIH HHS P50 CA236733NCI NIH HHS R01 CA244188NCI NIH HHS R01 CA281002NHGRI NIH HHS T32 HG000044NIGMS NIH HHS R35 GM118082NIGMS NIH HHS R35 GM122516
6 · The paper itselfAbstract
The β-catenin destruction complex (BDC) is a central node in WNT/β-catenin signaling, governing embryonic development and adult tissue homeostasis. Although recognized as a prime therapeutic target in colorectal cancer (CRC) for three decades, its dynamic architecture and biochemical complexity have hindered mechanistic understanding. Here, we systematically mapped the sequence-function landscape of the BDC using tiled base editor screens across four endogenous components-
Identifiers
PMID41278994
PMCPMC12633535
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