ArticlebioRxiv : the preprint server for biology2025
Matrix stiffness induces endothelial network senescence.
Jiyeon Song, Alexandra N Rindone, Ya Guan, Prarthana Sanjay Daswani, Jennifer H Elisseeff, Sharon Gerecht
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors.
Alexandra N RindoneTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21231, USA.
Ya GuanDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Prarthana Sanjay DaswaniTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21231, USA.
Jennifer H ElisseeffTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21231, USA.
Sharon GerechtDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6MRegional Biocontainment Laboratory (RBL)UC6AI058607 · NIAID · DUKE UNIVERSITY · PI WILLIAMS, R SANDERS · 2003 to 2005
$16.3MResources and Workforce Development for the Regional Biocontainment LaboratoriesUC7AI180254 · NIAID · DUKE UNIVERSITY · PI Herman F Staats · 2023 to 2026
$14.0MRegional Biocontainment Laboratories Facility and Building System Upgrades SupportG20AI167200 · NIAID · DUKE UNIVERSITY · PI STAATS, HERMAN F · 2021 to 2022
$6.6MJHU-Mayo-NIA Murine Senescence Mapping Program (JMN-MSMP)U54AG079779 · NIA · JOHNS HOPKINS UNIVERSITY · PI JENNIFER H ELISSEEFF · 2022 to 2026
$6.4MSenescence in the Foreign Body Response Across LifespanR01AG082965 · NIA · JOHNS HOPKINS UNIVERSITY · PI JENNIFER H ELISSEEFF · 2024 to 2026
$2.0MNCI NIH HHS P30 CA006973NIAID NIH HHS G20 AI167200NIAID NIH HHS UC6 AI058607NIAID NIH HHS UC7 AI180254NIA NIH HHS R01 AG082965NIA NIH HHS U54 AG079779
6 · The paper itselfAbstract
Identifying the drivers of cellular senescence that contribute to the decline in tissue function related to aging- and disease is critical for developing restorative interventions. Here, we investigated how increased mechanical stress from extracellular matrix (ECM) stiffening shapes endothelial cell (EC) senescence. We developed a 3D human
Identifiers
PMID41278992
PMCPMC12632338
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390