Evidence map›Paper›PMID 41278988›Full record

ArticlebioRxiv : the preprint server for biology2025

Myelin pathology is a key feature of X-linked Dystonia Parkinsonism.

Priya Prakash, Kerry C Limberg, Weimin Zhang, Yu Zhao, Klaudia F Laborc, Anna O'Keeffe, Bryanna C Vilnaigre, Heather Appleby, Michael R O'Dea, Cara Fernandez-Cerado and 13 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Priya PrakashInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York City, NY, USA.ORCID 0000-0003-2193-9669
Kerry C LimbergInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York City, NY, USA.ORCID 0009-0007-9583-1286
Weimin ZhangInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.ORCID 0000-0002-8836-1438
Yu ZhaoInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.ORCID 0000-0003-4659-9832
Klaudia F LaborcInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York City, NY, USA.
Anna O'KeeffeInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York City, NY, USA.ORCID 0000-0002-6135-7607
Bryanna C VilnaigreInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York City, NY, USA.
Heather ApplebyInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.
Michael R O'DeaInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York City, NY, USA.
Cara Fernandez-CeradoSunshine Care Foundation, 5800 Roxas City, Capiz, Philippines.
Gierold Paul A LegardaSunshine Care Foundation, 5800 Roxas City, Capiz, Philippines.
Michelle SySunshine Care Foundation, 5800 Roxas City, Capiz, Philippines.
Edwin L MuñozDepartment of Pathology, College of Medicine, University of the Philippines, Manila, Philippines.
Mark Angelo C AngDepartment of Pathology, College of Medicine, University of the Philippines, Manila, Philippines.
Cid Czarina E DiestaMovement Center of Makati Med Institute of Neurological, Neurosurgical and Behavioral Sciences, Makati City, Philippines.
Justin HanDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Ean NorenbergDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Ellen B PenneyDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0009-0000-0464-6501
D Cristopher BraggDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3203-6262
Adam C MarInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York City, NY, USA.ORCID 0000-0002-2095-2936
Ran BroshInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.ORCID 0000-0001-9714-8623
Jef D BoekeInstitute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.ORCID 0000-0001-5322-4946
Shane A LiddelowInstitute for Translational Neuroscience, NYU Grossman School of Medicine, New York City, NY, USA.ORCID 0000-0002-0840-1437

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
Supplement for Center for Synthetic Regulatory Genomics: Building CACNA1C alleles associated with Neuropsychiatric DisordersRM1HG009491 · NHGRI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jef D BOEKE · 2018 to 2026
$20.9M
Scanning Electron Microscope with 3ViewS10OD019974 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIANG, FENGXIA · 2016 to 2016
$1.1M
NCI NIH HHS P30 CA016087NHGRI NIH HHS RM1 HG009491NIH HHS S10 OD019974
6 · The paper itself

Abstract

X-linked Dystonia-Parkinsonism (XDP) is a progressive, adult-onset neurodegenerative movement disorder that predominantly affects males of Filipino descent

Identifiers

PMID41278988
PMCPMC12632464

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.