Evidence map›Paper›PMID 41278981›Full record

ArticlebioRxiv : the preprint server for biology2025

Preselection CD4

Esther Jeong Yoon Kim, Dominik A Aylard, Zoë Steier, Daisy Ortiz, Jean Choi, Stephanie Chen, Aaron Streets, Nir Yosef, Ellen A Robey

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Esther Jeong Yoon Kim *University of California, Berkeley, Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Berkeley, CA, USA.ORCID 0000-0003-4436-3826
Dominik A Aylard *University of California, Berkeley, Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Berkeley, CA, USA.
Zoë SteierMassachusetts Institute of Technology, Institute for Medical Engineering and Science, Cambridge, MA, USA.ORCID 0000-0003-1488-7995
Daisy OrtizUniversity of California, Berkeley, Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Berkeley, CA, USA.
Jean ChoiUniversity of California, Berkeley, Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Berkeley, CA, USA.
Stephanie ChenUniversity of California, Berkeley, Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Berkeley, CA, USA.
Aaron StreetsUniversity of California, Berkeley, Department of Bioengineering, Berkeley, CA, USA.ORCID 0000-0002-3909-8389
Nir YosefWeizmann Institute of Science, Department of Systems Immunology, Rehovot, Israel.ORCID 0000-0001-9004-1225
Ellen A RobeyUniversity of California, Berkeley, Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, Berkeley, CA, USA.ORCID 0000-0002-3630-5266

Funding

Signals That Control Thymocyte MigrationR01AI064227 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI ELLEN A ROBEY · 2006 to 2026
$7.4M
Spatial and temporal mapping of cell fate within lymphoid tissueR24AI145816 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROBEY, ELLEN A, STREETS, AARON · 2020 to 2024
$3.2M
NIAID NIH HHS R01 AI064227NIAID NIH HHS R24 AI145816
6 · The paper itself

Abstract

Modulation of TCR sensitivity during positive selection is critical to avoid negative selection and direct thymocytes into their appropriate lineage. Thymocytes just prior to positive selection (preselection) are highly responsive to low affinity self-ligands and are also actively rearranging their TCRα locus as they await a positive selection signal. Preselection DP thymocytes were thought to be relatively homogeneous and TCR modulation during this stage had not been previously described. Here we provide evidence for progressive gene expression changes within the preselection DP thymocyte population that correlates with a gradual loss of TCR responsiveness and a defect in upregulating TCR target genes associated with the CD4 fate. We relate these observations to the link between positive selection and T cell lineage commitment.

Indexed as

cell differentiationsignal transductionsingle-cell sequencingT cellsthymus

Identifiers

PMID41278981
PMCPMC12632616

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.