Evidence map›Paper›PMID 41278975›Full record

ArticlebioRxiv : the preprint server for biology2025

Transcriptional regulation of disease-relevant microglial activation programs.

Amanda McQuade, Reet Mishra, Venus Hagan, Weiwei Liang, Peter J Colias, Vincent Cele Castillo, Justin P Lubin, Verena Haage, Victoria Marshe, Masashi Fujita and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Amanda McQuadeInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.
Reet MishraInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.
Venus HaganInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.
Weiwei LiangInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.
Peter J ColiasDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Vincent Cele CastilloInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.
Justin P LubinDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, USA.
Verena HaageCenter for Translational & Computational Neuroimmunology, Department of Neurology & Taub Institute for the study of Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.
Victoria MarsheCenter for Translational & Computational Neuroimmunology, Department of Neurology & Taub Institute for the study of Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.
Masashi FujitaCenter for Translational & Computational Neuroimmunology, Department of Neurology & Taub Institute for the study of Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.
Layla GomesInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.
Thomas TaInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.
Olivia TeterInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.
Sarah E ChasinsDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, Berkeley, CA, USA.
Philip L De JagerCenter for Translational & Computational Neuroimmunology, Department of Neurology & Taub Institute for the study of Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.
James K NuñezDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Martin KampmannInstitute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-3819-7019

Funding

Mechanisms of epigenetic memory in human cellsR35GM155044 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI James Karlo Nunez · 2024 to 2026
$1.2M
NIGMS NIH HHS R35 GM155044
6 · The paper itself

Abstract

Microglia, the brain's innate immune cells, can adopt a wide variety of activation states relevant to health and disease. Dysregulation of microglial activation occurs in numerous brain disorders, and driving or inhibiting specific states could be therapeutic. To discover regulators of microglial activation states, we conducted CRISPR interference screens in iPSC-derived microglia for inhibitors and activators of six microglial states. We identified transcriptional regulators for each of these states and characterized 31 regulators at the single-cell transcriptomic and cell-surface proteome level in two distinct iPSC-derived microglia models. Finally, we functionally characterized several regulators.

Identifiers

PMID41278975
PMCPMC12632903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.