Evidence map›Paper›PMID 41278949›Full record

ArticlebioRxiv : the preprint server for biology2025

An antagonistic epigenetic mechanism regulating gene expression in pollen revealed through single-nucleus multiomics.

Colette L Picard, Lucia Ichino, Tyler J Buckley, Brandon A Boone, Jaewon Yun, Kevin D Abuhanna, Yi Zhang, Noah J Behrendt, Su May Lei Soe, Chongyuan Luo and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Colette L PicardDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Lucia IchinoMolecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.
Tyler J BuckleyMolecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.
Brandon A BooneMolecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.
Jaewon YunDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Kevin D AbuhannaDepartment of Human Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.
Yi ZhangDepartment of Human Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.
Noah J BehrendtDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Su May Lei SoeDepartment of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA.
Chongyuan LuoDepartment of Human Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.
Steven E JacobsenMolecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.

Funding

Characterization of the function of gene body DNA methylationF32GM136115 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PICARD, COLETTE LAFONTAINE · 2020 to 2022
$201k
NIGMS NIH HHS F32 GM136115
6 · The paper itself

Abstract

Arabidopsis MBD5, MBD6, and MBD7 are CG-specific methyl-readers with opposite functions: MBD5 and MBD6 (MBD5/6) repress methylated loci in pollen vegetative nuclei (VN), while MBD7 prevents transgene silencing, possibly by promoting DNA demethylation. Here we show that loss of

Identifiers

PMID41278949
PMCPMC12632923

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.