In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors.
Kaustav BeraDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.ORCID 0000-0002-0962-4368 Delaney L McNallyDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.
Bruce E KirkpatrickDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.ORCID 0000-0003-2862-3843 Nolan R PetrichDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.
F Max YavittDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.ORCID 0000-0002-9278-9082 Marilyne CoulombeSection of Developmental Biology, Department of Pediatrics, University of Colorado, Denver, CO, 80045, USA.
Michaela QuinteroDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0003-4181-0942 Nathaniel P SkillinDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.ORCID 0000-0003-1424-9037 Alex KhangDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.ORCID 0000-0002-1211-5740 Patrick S McGrathSection of Developmental Biology, Department of Pediatrics, University of Colorado, Denver, CO, 80045, USA.ORCID 0000-0002-1498-371X Linda C SamuelsonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Tanmay P LeleArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, 77840, USA.ORCID 0000-0001-8574-1251 Peter J DempseySection of Developmental Biology, Department of Pediatrics, University of Colorado, Denver, CO, 80045, USA.ORCID 0009-0009-9742-8452 Kristi S AnsethDepartment of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.ORCID 0000-0002-5725-5691 Funding
University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0MUniversity of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8MPOSTGRADUATE TRAINING IN CARDIOVASCULAR RESEARCHT32HL007822 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUTTRICK, PETER N., LEINWAND, LESLIE ANNE · 1996 to 2023
$6.2MSynthetic hydrogels to study formation and maintenance of intestinal cryptsR01DK120921 · NIDDK · UNIVERSITY OF COLORADO · PI KRISTI S. ANSETH, PETER J DEMPSEY · 2019 to 2026
$3.8MMechanisms of Intestinal Stem Cell Injury and RepairR01DK118023 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SAMUELSON, LINDA C. · 2018 to 2021
$1.7MLaser Scanning Confocal MicroscopeS10OD034320 · OD · UNIVERSITY OF COLORADO · PI DRAGAVON, JOSEPH · 2023 to 2023
$445kDefining the Notch niche for Intestinal Stem cellsF32DK142253 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Michaela Katherine Quintero · 2025 to 2026
$155kUnderstanding the intestinal regenerative response using patterned organoids in photo-tunable PEG hydrogelsF31DK126427 · NIDDK · UNIVERSITY OF COLORADO · PI YAVITT, MAX · 2021 to 2023
$114kIdentifying the Role of Fibroblast-Macrophage Crosstalk in Aortic Valve Stenosis Sexual DimorphismF32HL176073 · NHLBI · UNIVERSITY OF COLORADO · PI KHANG, ALEX · 2024 to 2024
$74kNCI NIH HHS P30 CA046934NHLBI NIH HHS F32 HL176073NHLBI NIH HHS T32 HL007822NIDDK NIH HHS F31 DK126427NIDDK NIH HHS F32 DK142253NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK118023NIDDK NIH HHS R01 DK120921NIH HHS S10 OD034320
6 · The paper itselfAbstract
Tissue architecture and function are influenced by mechanical cues. Yet, how cell nuclei sense forces within 3D tissues and dictate differentiation remains unknown as prior studies focused on isolated mesenchymal cells, which fail to fully predict tissue-level mechanical properties. We fill this knowledge gap utilizing live reporters and material-based organoid models. We posit the nucleus as an active mechanosensor of tissue shape, with levels of the nuclear scaffolding protein lamin-A varying across intestinal stem cell differentiation trajectory. Elevated forces on differentiated Paneth cell nuclei, in both organoids and tissue explants, increase lamin-A and nuclear wrinkling. Enhancing nuclear mechanotransduction primes cell differentiation, in otherwise stem promoting conditions, revealing that nuclear mechanics can direct stem cell fate. By engineering spatiotemporally controlled
Identifiers
PMID41278926
PMCPMC12633427
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