ArticlebioRxiv : the preprint server for biology2025
Planarian behavioral screening is a useful invertebrate model for evaluating seizurogenic chemicals.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Detecting adverse health effects of drugs and other chemicals early during chemical/drug development saves significant time and resources. Freshwater planarians are an emerging invertebrate model for rapid, cost-effective neurotoxicity screening. Because planarians exhibit seizure-like behavior when exposed to chemicals that cause seizures in mammals, such as N-methyl-D-aspartate (NMDA) and picrotoxin, they could be a useful first-tier model for seizure screening and thus reduce the need for slow and expensive mammalian tests. However, planarian seizure studies to date have been low-throughput and lacking the necessary standardization and automation to make this model a viable screening solution. Here, we present results from medium-throughput behavioral testing conducted in 48-well plates using two popular models for planarian pharmacological and toxicological studies:
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