Evidence map›Paper›PMID 41278902›Full record

ArticlebioRxiv : the preprint server for biology2025

Sleep-dependent clearance of brain lipids by peripheral blood cells.

Bumsik Cho, Diane E Youngstrom, Samantha Killiany, Camilo Guevara, Caitlin E Randolph, Connor H Beveridge, Pooja Saklani, Gaurav Chopra, Amita Sehgal

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Bumsik ChoDepartment of Neuroscience, Chronobiology and Sleep Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Diane E YoungstromDepartment of Neuroscience, Chronobiology and Sleep Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Samantha KillianyDepartment of Neuroscience, Chronobiology and Sleep Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Camilo GuevaraDepartment of Neuroscience, Chronobiology and Sleep Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Caitlin E RandolphDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.
Connor H BeveridgeDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.
Pooja SaklaniDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.
Gaurav ChopraDepartment of Chemistry, Purdue University, West Lafayette, IN, USA.
Amita SehgalDepartment of Neuroscience, Chronobiology and Sleep Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4M
Interaction between circadian and sleep circuitsR01NS048471 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI AMITA SEHGAL · 2005 to 2026
$4.8M
Cycling in a circadian circuitR37NS048471 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, AMITA · 2015 to 2021
$2.7M
Chemical instruments-aware distributed blockchain based open AI platform to accelerate drug discoveryU18TR004146 · NCATS · PURDUE UNIVERSITY · PI CHOPRA, GAURAV, JAYACHANDRAN, GUHA · 2022 to 2023
$1.1M
Cycling of circadium rhythm proteinsR56NS048471 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, AMITA · 2010 to 2010
$400k
NCATS NIH HHS U18 TR004146NCI NIH HHS P30 CA023168NINDS NIH HHS R01 NS048471NINDS NIH HHS R37 NS048471NINDS NIH HHS R56 NS048471
6 · The paper itself

Abstract

Sleep is typically viewed through a brain-centric lens, with little known about the role of the periphery. Here, we identify a sleep function for peripheral macrophage-like cells (hemocytes) in the

Identifiers

PMID41278902
PMCPMC12636575

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.