Evidence map›Paper›PMID 41278895›Full record

ArticlebioRxiv : the preprint server for biology2025

Dorsal Raphe Nucleus Enkephalin Peptide Modulates Behavioral Preference.

Kathryn Braden, Andrew Trinagel, Eric Acevedo, Alexandra E Bernstein, Marcela Arguello, Laura N Massó-Quiñones, Aidan Evans-Strong, Samantha S Dunn, Daniel C Castro

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Kathryn BradenORCID 0009-0004-6769-0824
Andrew Trinagel
Eric Acevedo
Alexandra E Bernstein
Marcela Arguello
Laura N Massó-Quiñones
Aidan Evans-Strong
Samantha S Dunn
Daniel C CastroORCID 0000-0001-8036-1313

Funding

Investigating non-canonical mechanisms of endogenous opioids on motivation in dorsal midbrainR01MH132504 · NIMH · WASHINGTON UNIVERSITY · PI Daniel Charles Castro · 2023 to 2026
$2.1M
Physiological and Molecular Mechanisms of Mu Opioid Receptors in Motivation and AffectR00DA049862 · NIDA · WASHINGTON UNIVERSITY · PI CASTRO, DANIEL CHARLES · 2022 to 2024
$747k
Physiological and Molecular Mechanisms of Mu Opioid Receptors in Motivation and AffectK99DA049862 · NIDA · UNIVERSITY OF WASHINGTON · PI CASTRO, DANIEL CHARLES · 2020 to 2021
$284k
Dissecting the role and mechanisms of mu opioid receptors in nucleus accumbensF32DA043999 · NIDA · WASHINGTON UNIVERSITY · PI CASTRO, DANIEL CHARLES · 2018 to 2019
$120k
NIDA NIH HHS F32 DA043999NIDA NIH HHS K99 DA049862NIDA NIH HHS R00 DA049862NIMH NIH HHS R01 MH132504
6 · The paper itself

Abstract

The endogenous opioid system is a powerful modulator of motivation and affect. The dorsal raphe nucleus (DRN) in the midbrain has been established as an important site of opioid action and is an integral hub in behavioral modulation. To investigate the functional significance of DRN opioid signaling in aversive and appetitive behaviors we disrupted preproenkephalin (Penk) in DRN using CRISPR-Cas9 technology in Penk-Cre mice. We found that CRISPR mediated knockdown of enkephalin peptide in the DRN (DRN

Identifiers

PMID41278895
PMCPMC12633406

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.