Evidence map›Paper›PMID 41278885›Full record

ArticlebioRxiv : the preprint server for biology2025

Genetic interaction of

Brittany M Hufft-Martinez, Dana N Thalman, An J Tran, Jeremy P Goering, Marta Stetsiv, Michael Moedritzer, Sarah C Wilson, Henry H Wang, Pamela V Tran, Irfan Saadi

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brittany M Hufft-MartinezDepartment of Cell Biology and Physiology, University of Kansas Medical Center.ORCID 0000-0002-2063-5420
Dana N ThalmanDepartment of Cell Biology and Physiology, University of Kansas Medical Center.ORCID 0000-0002-4727-5963
An J TranDepartment of Cell Biology and Physiology, University of Kansas Medical Center.
Jeremy P GoeringDepartment of Cell Biology and Physiology, University of Kansas Medical Center.
Marta StetsivDepartment of Cell Biology and Physiology, University of Kansas Medical Center.ORCID 0000-0003-3675-3082
Michael MoedritzerDepartment of Cell Biology and Physiology, University of Kansas Medical Center.
Sarah C WilsonDepartment of Cell Biology and Physiology, University of Kansas Medical Center.
Henry H WangDepartment of Cell Biology and Physiology, University of Kansas Medical Center.
Pamela V TranDepartment of Cell Biology and Physiology, University of Kansas Medical Center.ORCID 0000-0003-4619-4376
Irfan SaadiDepartment of Cell Biology and Physiology, University of Kansas Medical Center.ORCID 0000-0002-6250-6651

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Using PCORnet to Expand the DS-CONNECT Cohort Through Healthcare System Recruitment, Incorporating Electronic Health Records, and Assessing Self-DeterminationU54HD090216 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI COLOMBO, JOHN A. · 2016 to 2020
$6.2M
Molecular Regulation of Cell Development and Differentiation Phase III COBREP30GM122731 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI VIVIAN, JAY L · 2017 to 2021
$5.6M
NRSA Training CoreTL1TR002368 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Jennifer Lynn Goldman, NICOLE L NOLLEN · 2017 to 2026
$4.0M
Role of SPECC1L cytoskeletal protein in palate elevation dynamicsR01DE032825 · NIDCR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Irfan Saadi · 2023 to 2026
$2.4M
The Role of SPECC1L cytoskeletal protein in craniofacial development and malformationR01DE026172 · NIDCR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SAADI, IRFAN · 2016 to 2020
$1.9M
Super resolution microscope for the imaging core facilityS10OD023625 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NISHIMUNE, HIROSHI · 2019 to 2019
$987k
Spinning-Disk Confocal Microscope for Wide-Field, Super-Resolution, and Live-Cell ImagingS10OD032207 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SMITH, PETER G · 2022 to 2022
$600k
Investigating the protective effect of maternal Thm1 heterozygosity against cleft palateR21DE032515 · NIDCR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SAADI, IRFAN, TRAN, PAMELA VIVIAN · 2023 to 2024
$426k
In utero rescue of cleft palate using maternal administration of folic acidR21DE032742 · NIDCR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SAADI, IRFAN, TRAN, PAMELA VIVIAN · 2023 to 2024
$426k
Role of Specc1l in ciliogenesis during craniofacial developmentF31DE031181 · NIDCR · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MARTINEZ, BRITTANY M · 2021 to 2022
$72k
NCATS NIH HHS TL1 TR002368NICHD NIH HHS U54 HD090216NIDCR NIH HHS F31 DE031181NIDCR NIH HHS R01 DE026172NIDCR NIH HHS R01 DE032825NIDCR NIH HHS R21 DE032515NIDCR NIH HHS R21 DE032742NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P30 GM122731NIH HHS S10 OD023625NIH HHS S10 OD032207
6 · The paper itself

Abstract

Cilium formation and actin cytoskeleton dynamics are interconnected, with evidence showing that elevated filamentous actin (F-actin) negatively regulates primary cilia length. Loss of the cytoskeletal protein SPECC1L, which itself does not localize to cilia, leads to increased F-actin and shortened cilia. Depolymerizing F-actin in

Indexed as

actin cytoskeletonCiliogenesiscleft palatecraniofacial developmentgenetic interaction

Identifiers

PMID41278885
PMCPMC12637708

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.