Evidence map›Paper›PMID 41278877›Full record

ArticlebioRxiv : the preprint server for biology2025

PPARG directs trophoblast cell fate and establishment of the uterine-placental interface.

Esteban M Dominguez, Ayelen Moreno-Irusta, Khursheed Iqbal, Keting Chen, Alex Finlinson, Marc Parrish, Hiroaki Okae, Takahiro Arima, Geetu Tuteja, Michael J Soares

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Esteban M DominguezInstitute for Reproductive and Developmental Sciences, Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160.ORCID 0000-0003-3540-4411
Ayelen Moreno-IrustaInstitute for Reproductive and Developmental Sciences, Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160.ORCID 0000-0001-6810-6475
Khursheed IqbalInstitute for Reproductive and Developmental Sciences, Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160.ORCID 0000-0002-6742-4591
Keting ChenDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA 50011.
Alex FinlinsonDepartment of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS 66160.
Marc ParrishDepartment of Obstetrics and Gynecology, University of Kansas Medical Center, Kansas City, KS 66160.
Hiroaki OkaeDepartment of Trophoblast Research, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan.
Takahiro ArimaDepartment of Informative Genetics, Environment and Genome Research Center, Tohoku University Graduate School of Medicine, and Department of Molecular Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan.
Geetu TutejaDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA 50011.
Michael J SoaresInstitute for Reproductive and Developmental Sciences, Department of Pathology & Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS 66160.

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SUSAN J. BROWN · 2012 to 2026
$63.0M
TROPHOBLAST DIFFERENTIATIONR01HD020676 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MICHAEL J SOARES · 1986 to 2026
$10.1M
Trophoblast-Guided Uterine Transformation in the Establishment of PregnancyR01HD105734 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MICHAEL J SOARES · 2022 to 2026
$2.2M
Pathways Affecting Trophoblast DevelopmentR01HD112559 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MICHAEL J SOARES, Geetu Tuteja · 2024 to 2026
$1.9M
A new animal model for investigating the invasive trophoblast lineageR21HD104071 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI IQBAL, KHURSHEED · 2021 to 2022
$439k
Early Events in Extravillous Trophoblast Cell DifferentiationK99HD115834 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MORENO, AYELEN · 2024 to 2025
$261k
NICHD NIH HHS K99 HD115834NICHD NIH HHS R01 HD020676NICHD NIH HHS R01 HD105734NICHD NIH HHS R01 HD112559NICHD NIH HHS R21 HD104071NIGMS NIH HHS P20 GM103418
6 · The paper itself

Abstract

The expansion and differentiation of trophoblast stem (

Indexed as

hemochorial placentaPPARGtrophoblast cell invasion

Identifiers

PMID41278877
PMCPMC12632317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.