Evidence map›Paper›PMID 41278865›Full record

ArticlebioRxiv : the preprint server for biology2025

CRISPRi Screen Identifies a Novel Growth Suppressor lncRNA,

Christy Montano, Eric Malekos, Sergio Covarrubias, Sol Katzman, Lisa Sudek, Jillian Ward, Susan Carpenter

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christy MontanoDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, California, USA.ORCID 0009-0009-7027-8458
Eric MalekosDepartment of Biomolecular Engineering, University of California Santa Cruz, California, USA.
Sergio CovarrubiasDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, California, USA.
Sol KatzmanDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, California, USA.
Lisa SudekDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, California, USA.
Jillian WardDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, California, USA.
Susan CarpenterDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, California, USA.ORCID 0000-0002-5600-5404

Funding

High throughput functional characterization of lncRNAs in macrophage biologyR35GM137801 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CARPENTER, SUSAN · 2020 to 2024
$2.2M
Identification and characterization of small open reading frames translated during inflammationF31AI179201 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI MALEKOS, ERIC · 2023 to 2025
$134k
NIAID NIH HHS F31 AI179201NIGMS NIH HHS R35 GM137801
6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is a heterogeneous disease that arises from dysregulated myeloid proliferation. We performed a high-throughput CRISPR interference (CRISPRi) screen in the THP-1 monocytic cancer cell line to identify long noncoding RNAs (lncRNAs) that play a role in contributing to cell proliferation. Our screen identified

Identifiers

PMID41278865
PMCPMC12636565

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.