Evidence map›Paper›PMID 41278860›Full record

ArticlebioRxiv : the preprint server for biology2025

The LINC complex component Kms1 and CENP-B protein Cbp1 cooperate to enforce faithful homology-directed DNA repair at the nuclear periphery in

Alyssa Laffitte, Dongxu Lin, Yingzhen Jenny Tian, Na Liu, C Patrick Lusk, Simon G J Mochrie, Megan C King

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Alyssa LaffitteDepartment of Cell Biology, Yale School of Medicine, New Haven, CT, USA, 06520.
Dongxu LinDepartment of Cell Biology, Yale School of Medicine, New Haven, CT, USA, 06520.
Yingzhen Jenny TianDepartment of Physics, Yale University, New Haven, CT, USA, 06510.
Na LiuDepartment of Cell Biology, Yale School of Medicine, New Haven, CT, USA, 06520.
C Patrick LuskDepartment of Cell Biology, Yale School of Medicine, New Haven, CT, USA, 06520.ORCID 0000-0003-4703-0533
Simon G J MochrieDepartment of Physics, Yale University, New Haven, CT, USA, 06510.
Megan C KingDepartment of Cell Biology, Yale School of Medicine, New Haven, CT, USA, 06520.ORCID 0000-0002-1688-2226

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007499 · NIGMS · YALE UNIVERSITY · PI CARLSON, JOHN R, REINKE, VALERIE J · 1985 to 2022
$13.9M
The role of nuclear architecture in adaptationDP2OD008429 · OD · YALE UNIVERSITY · PI KING, MEGAN C · 2011 to 2011
$2.5M
The genetic and non-genetic responses of chromatin to forceR35GM153474 · NIGMS · YALE UNIVERSITY · PI MEGAN C KING · 2024 to 2026
$1.3M
The Effect of Subnuclear Compartmentalization on DNA Double-Strand Break RepairF31GM143917 · NIGMS · YALE UNIVERSITY · PI LAFFITTE, ALYSSA · 2022 to 2023
$94k
NIGMS NIH HHS F31 GM143917NIGMS NIH HHS R35 GM153474NIGMS NIH HHS T32 GM007499NIH HHS DP2 OD008429
6 · The paper itself

Abstract

While homologous recombination (HR) is often considered to be an error-free DNA repair mechanism, the fidelity of this pathway depends on the cell's ability to engage the ideal template, the replicated sister chromatid. This is particularly challenging during repair of repetitive genome regions for which non-allelic sequences can errantly be used as templates. Here, we develop a model to study spontaneous DNA damage and repair that occurs at repetitive protein coding genes of the

Identifiers

PMID41278860
PMCPMC12632457

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.