Evidence map›Paper›PMID 41278853›Full record

ArticlebioRxiv : the preprint server for biology2025

Characterization of Gait Kinematics and Muscle Function in Becker Muscular Dystrophy Pigs: a pilot study.

Aaron B Morton, Jacob A Kendra, Shadi Golpasandi, Macie Mackey, Haley Russell, Connor Hendrie, Kuanting Chen, Zoe E Kiefer, Jennifer M Yentes, Jason W Ross and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Aaron B MortonDepartment of Kinesiology and Sport Management, College of Education and Human Development, Texas A&M University, College Station, TX, USA, 77845.ORCID 0000-0002-9790-705X
Jacob A KendraDepartment of Kinesiology and Sport Management, College of Education and Human Development, Texas A&M University, College Station, TX, USA, 77845.ORCID 0009-0002-9940-8497
Shadi GolpasandiDepartment of Kinesiology and Sport Management, College of Education and Human Development, Texas A&M University, College Station, TX, USA, 77845.ORCID 0009-0007-4932-6027
Macie MackeyDepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA, 77843.
Haley RussellDepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA, 77843.
Connor HendrieDepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA, 77843.
Kuanting ChenDepartment of Kinesiology and Sport Management, College of Education and Human Development, Texas A&M University, College Station, TX, USA, 77845.ORCID 0000-0002-8665-531X
Zoe E KieferDepartment of Animal Science, College of Agriculture and Life Sciences, Iowa State University, Ames, IA, USA, 50011.ORCID 0000-0002-3064-2384
Jennifer M YentesDepartment of Kinesiology and Sport Management, College of Education and Human Development, Texas A&M University, College Station, TX, USA, 77845.
Jason W RossDepartment of Animal Science, College of Agriculture and Life Sciences, Iowa State University, Ames, IA, USA, 50011.ORCID 0000-0003-4950-2258
Joshua T SelsbyDepartment of Animal Science, College of Agriculture and Life Sciences, Iowa State University, Ames, IA, USA, 50011.ORCID 0000-0003-3797-7539
Nicolaas E P DeutzDepartment of Kinesiology and Sport Management, College of Education and Human Development, Texas A&M University, College Station, TX, USA, 77845.ORCID 0000-0001-5845-6447
Peter P NghiemDepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA, 77843.ORCID 0000-0002-8796-8123

Funding

NIAMS NIH HHS L40 AR077899
6 · The paper itself

Abstract

Vertebrate animal models of Becker muscular dystrophy (BMD) have been developed. Here, we characterized the gait kinematics and muscle function of a naturally occurring BMD pig model of dystrophin insufficiency. BMD pigs tended to have alterations in hip range of motion (ROM): hip (67%, 95% CI -0.64 to 14.12 degrees). While parameters were unaltered in extensor muscles, the dystrophin levels in flexor tibiotarsal joint muscles correlated with fatigue index as well as reduced isometric force (48%, 95% CI -1.86 to -0.61 N-m), and a 33% increase in fatigue index (95% CI -36.25 to 96.71 percent); the extensor muscles had no observable reductions in muscle force, with a 48% increase in fatigue index (95% CI -232.6 to 472.6 percent). Histological analysis of muscle biopsies supported a BMD phenotype in the flexor muscles of BMD pigs, with a 75% (95% CI -55.14 to -15.66 percent) decrease in large and a 43% (95% CI 17.74 to 57.38 percent) increase in small muscle fiber cross-sectional area. Dystrophin protein abundance was 28% less in flexor muscles from BMD pigs (95% CI -49.63 to 11.41 arbitrary units). Together, our model may serve as a clinically relevant model of BMD to assess safety and efficacy of therapeutics.

Indexed as

Duchenne muscular dystrophyGait AnalysisLarge animal modelPorcinePreclinical ModelSkeletal Muscle Regeneration

Identifiers

PMID41278853
PMCPMC12632609

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.