Evidence map›Paper›PMID 41278848›Full record

ArticlebioRxiv : the preprint server for biology2025

Conkazal-M1 from the MKAVA family of conotoxins - a dual-function protease inhibitor and neuroactive peptide.

Celeste M Hackney, Thomas Lund Koch, Nicklas Lund Ryding, Aymeric Rogalski, Kevin Chase, Matías Leonel Giglio, Samuel S Espino, Zildjian G Acyatan, Maren Watkins, Baldomero M Olivera and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Celeste M HackneyDepartment of Biology, Linderstrøm-Lang Centre for Protein Science, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-3009-0495
Thomas Lund KochDepartment of Biochemistry, University of Utah, Salt Lake City, Utah, United States of America.
Nicklas Lund RydingDepartment of Biology, Linderstrøm-Lang Centre for Protein Science, University of Copenhagen, Copenhagen, Denmark.
Aymeric RogalskiDepartment of Biochemistry, University of Utah, Salt Lake City, Utah, United States of America.
Kevin ChaseSchool of Biological Sciences, University of Utah, Salt Lake City, Utah, United States of America.
Matías Leonel GiglioSchool of Biological Sciences, University of Utah, Salt Lake City, Utah, United States of America.
Samuel S EspinoSchool of Biological Sciences, University of Utah, Salt Lake City, Utah, United States of America.
Zildjian G AcyatanDepartment of Biochemistry, University of Utah, Salt Lake City, Utah, United States of America.
Maren WatkinsSchool of Biological Sciences, University of Utah, Salt Lake City, Utah, United States of America.
Baldomero M OliveraSchool of Biological Sciences, University of Utah, Salt Lake City, Utah, United States of America.
Helena Safavi-HemamiDepartment of Biochemistry, University of Utah, Salt Lake City, Utah, United States of America.
Kaare TeilumDepartment of Biology, Linderstrøm-Lang Centre for Protein Science, University of Copenhagen, Copenhagen, Denmark.
Lars EllgaardDepartment of Biology, Linderstrøm-Lang Centre for Protein Science, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-7018-0137

Funding

“Conus venom peptides and their molecular targets: Using pharmaconomics and neuroethology as a framework for discovery”R01GM144719 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI OLIVERA, BALDOMERO M, RAGHURAMAN, SHRINIVASAN · 2022 to 2025
$2.5M
NIGMS NIH HHS R01 GM144719
6 · The paper itself

Abstract

Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents. Here, we provide the first experimental characterization of a conotoxin from the MKAVA superfamily, conkazal-M1, from

Indexed as

Cone snailsconkazalconotoxinKazal-type protease inhibitorKunitz domainmolecular evolutionschistosomin

Identifiers

PMID41278848
PMCPMC12637466

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.