Evidence map›Paper›PMID 41278837›Full record

ArticlebioRxiv : the preprint server for biology2025

Complement Factor H and its

Yumiko Oshima, Katarzyna A Hussey, Joanna Hagen, Zeljka Smit-McBride, Maya Moorthy, Joanne A Matsubara, Martin Flajnik, Robert J Johnston, Bruce E Vogel

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yumiko OshimaDepartment of Pharmacology and Physiology, University of Maryland School of Medicine, University of Maryland, Baltimore, MD 21201.ORCID 0009-0001-7766-656X
Katarzyna A HusseyDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21211.ORCID 0000-0002-5046-2815
Joanna HagenDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21211.ORCID 0000-0002-7576-6137
Zeljka Smit-McBrideDepartment of Ophthalmology & Vision Science, Vitreoretinal Research Lab, University of California, Davis, Davis, CA 95616.ORCID 0000-0003-0275-8088
Maya MoorthyDepartment of Pharmacology and Physiology, University of Maryland School of Medicine, University of Maryland, Baltimore, MD 21201.ORCID 0009-0000-3661-4942
Joanne A MatsubaraDepartment of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V5Z 3N9, Canada.ORCID 0000-0002-3689-3117
Martin FlajnikDepartment of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC V5Z 3N9, Canada.ORCID 0000-0002-2792-5084
Robert J JohnstonDepartment of Biology, The Johns Hopkins University, Baltimore, MD 21211.ORCID 0000-0002-5775-6218
Bruce E VogelDepartment of Pharmacology and Physiology, University of Maryland School of Medicine, University of Maryland, Baltimore, MD 21201.ORCID 0000-0002-2576-3843

Funding

VISION RESEARCH CORE GRANTP30EY012576 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI Thomas M. Glaser · 1999 to 2026
$18.9M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Molecular Genetics of a Complement Factor H homologR01EY032868 · NEI · UNIVERSITY OF MARYLAND BALTIMORE · PI VOGEL, BRUCE E · 2021 to 2025
$1.9M
NEI NIH HHS P30 EY012576NEI NIH HHS R01 EY032868NIH HHS P40 OD010440
6 · The paper itself

Abstract

Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, is characterized by progressive degeneration of retinal photoreceptors. Current disease models propose AMD pathogenesis is a consequence of cytolytic damage and tissue inflammation that result from defective repression of alternative complement pathway activity by complement factor H (CFH). However, recent studies demonstrate functions for CFH that are outside of its established role in the alternative complement pathway, suggesting that novel CFH-mediated mechanisms may influence AMD initiation and progression. Our previous demonstration that CFH and its nematode homolog, CFH-1, modulate inversin/NPHP-2 accumulation in vertebrate photoreceptor and

Identifiers

PMID41278837
PMCPMC12632885

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.