Evidence map›Paper›PMID 41278836›Full record

ArticlebioRxiv : the preprint server for biology2025

Kinase KEY1 controls pyrenoid condensate size throughout the cell cycle by disrupting phase separation interactions.

Shan He, Linnea M Lemma, Alejandro Martinez-Calvo, Guanhua He, Jessica H Hennacy, Lianyong Wang, Sabrina L Ergun, Ashwani K Rai, Colton Wang, Luke Bunday and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Shan HeDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Linnea M LemmaHoward Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0001-8482-4573
Alejandro Martinez-CalvoPrinceton Center for Theoretical Science, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-2109-8145
Guanhua HeDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Jessica H HennacyDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Lianyong WangDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0003-0906-8346
Sabrina L ErgunDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-6539-8764
Ashwani K RaiDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-0041-0662
Colton WangDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Luke BundayDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Angelo Kayser-BrowneDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Quan WangLewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0001-7692-6721
Clifford P BrangwynneHoward Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-1350-9960
Ned S WingreenDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0001-7384-2821
Martin C JonikasDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-9519-6055

Funding

Learning principles from the pyrenoid, a phase-separated organelleR01GM140032 · NIGMS · PRINCETON UNIVERSITY · PI JONIKAS, MARTIN CASIMIR, WINGREEN, NED S · 2021 to 2024
$2.0M
NIGMS NIH HHS R01 GM140032
6 · The paper itself

Abstract

Biomolecular condensates spatially organize cellular functions, but the regulation of their size, number, dissolution, and re-condensation is poorly understood. The pyrenoid, an algal biomolecular condensate that mediates one-third of global CO

Identifiers

PMID41278836
PMCPMC12632510

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.