ArticlebioRxiv : the preprint server for biology2025
Activation of the noncanonical inflammasome-GSDMD pathway triggers pyroptosis in bone marrow and promotes periosteal bone formation.
Wei Zou, Chun Wang, Yongjia Li, Wentong Jia, Steven L Teitelbaum, Gabriel Mbalaviele
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors.
Wei ZouDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-8081-268X Chun WangDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-4635-8668 Yongjia LiDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.
Wentong JiaDivision of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Steven L TeitelbaumDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.
Gabriel MbalavieleDivision of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-4660-0952 Funding
Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8MDifferential Inflammasome Regulation in the pathogenesis of S. aureus osteomyelitisR01AI161022 · NIAID · WASHINGTON UNIVERSITY · PI CASSAT, JAMES E, MBALAVIELE, GABRIEL · 2021 to 2025
$3.4MMechanisms of AVB3 Integrin Mediated Bone ResorptionR37AR046523 · NIAMS · WASHINGTON UNIVERSITY · PI TEITELBAUM, STEVEN L · 2010 to 2019
$3.3MMolecular pathways of calcium pyrophosphate deposition diseaseR01AG077732 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI Gabriel Mbalaviele, Ann K Rosenthal · 2022 to 2026
$2.4MHepatic steatosis promotes liver metastasisR01CA258325 · NCI · WASHINGTON UNIVERSITY · PI Nidhi Rohatgi · 2022 to 2026
$2.3MFAT TALKS TO BONER01DK111389 · NIDDK · WASHINGTON UNIVERSITY · PI TEITELBAUM, STEVEN L · 2017 to 2021
$1.9MRole of gasdermin D in bone resorptionR01AR076758 · NIAMS · WASHINGTON UNIVERSITY · PI MBALAVIELE, GABRIEL · 2020 to 2024
$1.9MCabinet microCT System for Musculoskeletal Specimen ImagingS10OD028573 · OD · WASHINGTON UNIVERSITY · PI SILVA, MATTHEW J · 2020 to 2020
$407kNCI NIH HHS R01 CA258325NIAID NIH HHS R01 AI161022NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR076758NIAMS NIH HHS R37 AR046523NIA NIH HHS R01 AG077732NIDDK NIH HHS R01 DK111389NIH HHS S10 OD028573
6 · The paper itselfAbstract
Evidence indicating that inflammation is commonly associated with ectopic osteogenesis in certain autoimmune and infectious conditions challenges the dogma that inflammatory responses always suppress bone formation. In this study, we find that systemic administration of lipopolysaccharide (LPS) to mice causes not only inflammation in bone marrow, as expected, but also stimulates periosteal bone formation. This response can be reproduced
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PMID41278813
PMCPMC12633396
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