Evidence map›Paper›PMID 41278796›Full record

ArticlebioRxiv : the preprint server for biology2025

Adipose-mimetic granular hydrogels uncover biophysical cues driving breast cancer invasion.

Brianna K Knode, Garrett F Beeghly, Brittany E Schutrum, Dong Wang, Yitong Zheng, Alice Battistella, Ruchi Goswami, Chi-Yong Eom, Aline Bozec, Jochen Guck and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Brianna K KnodeNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.ORCID 0000-0003-2957-8044
Garrett F BeeghlyNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Brittany E SchutrumNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Dong WangDepartment of Mechanical Engineering, Yale University, New Haven, CT, USA.
Yitong ZhengDepartment of Mechanical Engineering, Yale University, New Haven, CT, USA.
Alice BattistellaMax Planck Institute for the Science of Light & Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany.
Ruchi GoswamiMax Planck Institute for the Science of Light & Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany.
Chi-Yong EomNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Aline BozecDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany.
Jochen GuckMax Planck Institute for the Science of Light & Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany.ORCID 0000-0002-1453-6119
Nozomi NishimuraNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Salvatore GirardoMax Planck Institute for the Science of Light & Max-Planck-Zentrum für Physik und Medizin, Erlangen, Germany.
Corey S O'HernDepartment of Mechanical Engineering, Yale University, New Haven, CT, USA.
Claudia FischbachNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-9368-0150

Funding

Project 3: Physical and Metabolic Constraints of Cancer Cell InvasionU54CA210184 · NCI · CORNELL UNIVERSITY · PI LAMMERDING, JAN · 2016 to 2020
$10.2M
Mechanical properties of adipose tissue and its effect on breast cancerR01CA276392 · NCI · CORNELL UNIVERSITY · PI Claudia Fischbach, Corey O'Hern · 2023 to 2026
$2.1M
Metabolic regulation of exosome biogenesis as a determinant of cancer cell metastasis.R01CA259195 · NCI · CORNELL UNIVERSITY · PI MARC A ANTONYAK, Claudia Fischbach · 2022 to 2026
$2.1M
Broad wavelength range Zeiss 780 NLO/confocal system for the Cornell Imaging CoreS10OD018516 · OD · CORNELL UNIVERSITY · PI ZIPFEL, WARREN R · 2014 to 2014
$834k
Zeiss LSM710 Confocal Microscope for Shared Imaging FacilityS10RR025502 · NCRR · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2009 to 2009
$500k
Hypertrophic adipocytes as biophysical mediators of breast cancer progressionF31CA278410 · NCI · CORNELL UNIVERSITY · PI BEEGHLY, GARRETT F · 2023 to 2024
$74k
NCI NIH HHS F31 CA278410NCI NIH HHS R01 CA259195NCI NIH HHS R01 CA276392NCI NIH HHS U54 CA210184NCRR NIH HHS S10 RR025502NIH HHS S10 OD018516
6 · The paper itself

Abstract

Breast cancer cells invade mammary adipose tissue during initial stages of metastasis but how the physical properties of adipose tissue regulate this process remains unclear. Here, we combined single cell mechanical characterization of primary adipocytes with microfluidic hydrogel fabrication, quantitative multiparametric imaging, Discrete Element Method (DEM) simulations, and

Indexed as

adipose modelingbreast cancerECM architecturegranular hydrogelTME mechanics

Identifiers

PMID41278796
PMCPMC12633341

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.