Evidence map›Paper›PMID 41278789›Full record

ArticlebioRxiv : the preprint server for biology2025

Control of gene output by intron RNA structure.

Leonard Schärfen, Pernille Bech, Paulina Podszywałow-Bartnicka, Karla M Neugebauer

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Leonard SchärfenDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520, USA.ORCID 0000-0003-0234-7609
Pernille BechDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520, USA.ORCID 0009-0009-3230-3165
Paulina Podszywałow-BartnickaDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520, USA.ORCID 0000-0002-4965-828X
Karla M NeugebauerDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520, USA.ORCID 0000-0002-3835-6761

Funding

Cross-regulation between transcription and pre-mRNA splicingR01GM112766 · NIGMS · YALE UNIVERSITY · PI Karla M Neugebauer · 2015 to 2026
$5.3M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2M
NIGMS NIH HHS R01 GM112766NIH HHS S10 OD030363
6 · The paper itself

Abstract

Intron removal through pre-mRNA splicing is a central step in gene expression across Eukarya. The process initiates with the recognition of intronic sequence elements (splice sites) by highly conserved RNA-protein components of the spliceosome.

Indexed as

MPRARNA StructureSplicingStructure Prediction

Identifiers

PMID41278789
PMCPMC12637734

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.