ArticlebioRxiv : the preprint server for biology2025
Estrogen Dependent Variation in the Contributions of TRPM4 and TRPM5 to Fat Taste.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sex differences in physiology have garnered significant interest of late; however, comparatively little is known about the effects of sex on the function of the peripheral taste system. Previously, we have shown that fat taste functions in a sexually dimorphic manner using molecular, cellular, and behavioral assays, and that a subtype of estrogen receptor (ER) proteins are highly expressed in Type II (receptor) cells. The underlying mechanisms of estrogen's action, though, remain unknown. Here, we sought to better understand estrogen's role in fat taste transduction at the molecular level by initially focusing on the transient receptor potential channels types M4 ( SUMMARY: The current manuscript shows sex differences in fat taste signaling and identifies functional variations in specific transduction elements in taste cells that respond to sex hormones, such as estrogen, that may mediate differences in peripheral fat taste pathways.
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