ArticlebioRxiv : the preprint server for biology2025
Brain dynamics of mental manipulation.
David R Quiroga-Martinez, Tianyu He, Gemma Fernández-Rubio, Leonardo Bonetti, Alejandro O Blenkmann, Tor Endestad, Anne-Kristin Solbakk, Torstein R Meling, Martin Fabricius, Olivia Kim-McManus and 5 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Tianyu HeDepartment of Neuroscience, UC Berkeley.
Gemma Fernández-RubioCenter for Music in the Brain, Department of Clinical Medicine, Aarhus University & The Royal Academy of Music, Aarhus/Aalborg, Denmark.ORCID 0000-0003-4646-1315 Leonardo BonettiCenter for Music in the Brain, Department of Clinical Medicine, Aarhus University & The Royal Academy of Music, Aarhus/Aalborg, Denmark.
Alejandro O BlenkmannDepartment of Psychology, University of Oslo, Norway.
Tor EndestadDepartment of Psychology, University of Oslo, Norway.
Anne-Kristin SolbakkDepartment of Psychology, University of Oslo, Norway.
Torstein R MelingDepartment of Neurosurgery, Copenhagen University Hospital.
Martin FabriciusDepartment of Clinical Neurophysiology, Copenhagen University Hospital.
Olivia Kim-McManusDepartment of Neurosciences, UC San Diego.
Jon T WillieDepartment of Neurosurgery, Washington University School of Medicine, St. Louis.
Mohammad DastjerdiDepartment of Neurology, Loma Linda University.
Jack J LinDepartment of Neurology, UC Davis.
Robert T KnightDepartment of Neuroscience, UC Berkeley.
Funding
Project 5: ComputationalP50MH109429 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI Robert Thomas Knight · 2017 to 2026
$25.3MTraining and DisseminationP41EB018783 · NIBIB · WADSWORTH CENTER · PI Theresa M. Vaughan · 2014 to 2026
$15.4MNeural circuit theory and trained recurrent network modeling of rapid learningU19NS107609 · NINDS · UNIVERSITY OF WASHINGTON · PI BUFFALO, ELIZABETH A · 2018 to 2022
$12.6MAttention, Orientation and the Human Prefrontal CortexR01NS021135 · NINDS · UNIVERSITY OF CALIFORNIA DAVIS · PI Robert Thomas Knight · 1985 to 2026
$6.5MBCI2000: Software Resource for Adaptive Neurotechnology ResearchU24NS109103 · NINDS · WASHINGTON UNIVERSITY · PI BRUNNER, PETER · 2019 to 2024
$2.8MMechanisms of Amygdala-Mediated Memory Enhancement in HumansR01MH120194 · NIMH · WASHINGTON UNIVERSITY · PI WILLIE, JON TIMOTHY · 2020 to 2024
$1.8MBCI2000+: A Software Platform for Adaptive NeurotechnologiesR01EB026439 · NIBIB · WASHINGTON UNIVERSITY · PI BRUNNER, PETER · 2018 to 2022
$1.5MDynamics and Causal Functions of Large-Scale Cortical and Subcortical NetworksU01NS108916 · NINDS · WADSWORTH CENTER · PI WOLPAW, JONATHAN RICKEL · 2018 to 2019
$1.4MNIBIB NIH HHS P41 EB018783NIBIB NIH HHS R01 EB026439NIMH NIH HHS P50 MH109429NIMH NIH HHS R01 MH120194NINDS NIH HHS R01 NS021135NINDS NIH HHS U01 NS108916NINDS NIH HHS U19 NS107609NINDS NIH HHS U24 NS109103
6 · The paper itselfAbstract
Humans effortlessly juggle their internal thoughts, but the neuronal dynamics that support mental manipulation are largely unknown. Leveraging the high spatiotemporal fidelity of intracranial recordings in humans (N = 30), we provide evidence that mental sound manipulation involves the inhibition of sensory cortex and the coordinated engagement of memory and control networks. This modulation manifests in two ways. First, there is a shift in the balance between faster (> 30 Hz) and slower (< 30 Hz) dynamics in primary and secondary auditory areas, suggesting a decrease in local excitability. Second, there is a distributed increase in oscillatory synchrony (6-10 Hz), which predicts imagery vividness and task performance. This evidence points to a key role of local excitability and inter-areal synchrony in the manipulation of thought.
Identifiers
PMID41278767
PMCPMC12633419
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