Evidence map›Paper›PMID 41278761›Full record

ArticlebioRxiv : the preprint server for biology2025

Protease-Resistant Azapeptide GLP-1 Analogue Improves Metabolic Control in Diet-Induced Obesity.

Mingzhu He, Kai Fan Cheng, Sonya VanPatten, Marcelo D T Torres, Bayan Al Jabari, Ibrahim T Mughrabi, Borja Ballarín-González, Myoungsun Son, Cesar de la Fuente-Nunez, Yousef Al-Abed

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mingzhu HeThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.ORCID 0000-0001-7779-2411
Kai Fan ChengThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.ORCID 0000-0001-6827-9827
Sonya VanPattenThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.ORCID 0000-0001-9304-4579
Marcelo D T TorresMachine Biology Group, Departments of Psychiatry and Microbiology, Institute for Biomedical Informatics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Bayan Al JabariThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Ibrahim T MughrabiInstitute of Bioelectronic Medicine, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY USA.ORCID 0000-0001-8057-6146
Borja Ballarín-GonzálezNovo Nordisk A/S, Måløv, Denmark.
Myoungsun SonInstitute of Molecular Medicine, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.ORCID 0000-0002-0655-3859
Cesar de la Fuente-NunezMachine Biology Group, Departments of Psychiatry and Microbiology, Institute for Biomedical Informatics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-2005-5629
Yousef Al-AbedThe Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.

Funding

Combining chemical and computational tools for predictive models of microbiome communitiesR35GM138201 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI DE LA FUENTE, CESAR · 2020 to 2024
$1.8M
NIGMS NIH HHS R35 GM138201
6 · The paper itself

Abstract

Peptide therapeutics are limited by rapid proteolysis and short half-lives. Azapeptides, created by replacing one or more α-carbon(s) on the peptide backbone with nitrogen atom(s), offer a strategy to improve peptide stability while preserving functional efficiency, yet their clinical potential has remained underexplored. Herein, we report the design, synthesis,

Indexed as

azapeptideGLP-1 receptor agonist (GLP-1RA)high-fat diet-induced obesity (HF-DIO)

Identifiers

PMID41278761
PMCPMC12632547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.