ArticlebioRxiv : the preprint server for biology2025
Tissue-specific regulation of PNPLA3 promotes lipid remodeling in response to dietary and temperature stress.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A variant in PNPLA3, an enzyme that promotes transfer of long-chain polyunsaturated fatty acids (LCPUFAs) from triglycerides to phospholipids in lipid droplets (LDs), is a major risk factor for steatotic liver disease. At thermoneutrality, PNPLA3 is easily detected in liver and increases with feeding; the protein is undetectable in adipose tissue, despite significantly higher
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