Evidence map›Paper›PMID 41278704›Full record

ArticlebioRxiv : the preprint server for biology2025

IGF-1 from bone marrow Adipoq-lineage cells stimulates endocortical bone formation in mature female mice.

Joshua C Bertels, Jasmin Koehnken Sawall, Brian Dulmovits, Xiaobin Liu, Ashley Phan, Xing Ji, Fangfang Song, Christopher Thom, Fanxin Long

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Joshua C BertelsDepartment of Surgery, Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Jasmin Koehnken SawallDepartment of Surgery, Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Brian DulmovitsDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Xiaobin LiuDepartment of Surgery, Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ashley PhanDepartment of Surgery, Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Xing JiDepartment of Surgery, Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Fangfang SongDepartment of Surgery, Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Christopher ThomDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Fanxin LongDepartment of Surgery, Translational Research Program in Pediatric Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Funding

Illuminating adipo-osteoprogenitors in the bone marrowR01AG077911 · NIA · CHILDREN'S HOSP OF PHILADELPHIA · PI Fanxin Long · 2023 to 2026
$1.8M
The cell metabolism basis for bone complications in type I diabetesR01DK125498 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI LONG, FANXIN · 2021 to 2024
$1.8M
Determining genetic mechanisms that drive in vitro hematopoiesisR00HL177827 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Christopher Stephen Thom · 2025 to 2026
$890k
Determining genetic mechanisms that drive in vitro hematopoiesisK99HL156052 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI THOM, CHRISTOPHER STEPHEN · 2021 to 2024
$670k
NHLBI NIH HHS K99 HL156052NHLBI NIH HHS R00 HL177827NIA NIH HHS R01 AG077911NIDDK NIH HHS R01 DK125498
6 · The paper itself

Abstract

Insulin-like growth factor 1 (IGF-1) is an anabolic signal promoting growth, differentiation and function of both embryonic and postnatal tissues. Both endocrine and paracrine functions of IGF-1 have been documented to regulate bone growth and bone marrow hematopoiesis. Local production of IGF-1 from various cell types may contribute differently to the overall bioactivity of IGF-1 in bone, but relevant sources and mechanisms are yet to be fully elucidated. Here we report that the Adipoq

Identifiers

PMID41278704
PMCPMC12637688

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.