Evidence map›Paper›PMID 41278677›Full record

ArticlebioRxiv : the preprint server for biology2025

Pharmacological reduction of neutrophil infiltration reduces

Orlaith Keenan, Joshua Soto Ocaña, Alexa Semon, Tiffany H Zhou, Emma E Furth, Gavyn Chern Wei Bee, Daniel L Aldridge, Juliana Diamantino, Christopher A Hunter, Ken Cadwell and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Orlaith KeenanDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA.ORCID 0000-0001-6973-1424
Joshua Soto OcañaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA.ORCID 0000-0002-8898-6630
Alexa SemonDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA.ORCID 0000-0002-0551-1446
Tiffany H ZhouDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA.ORCID 0009-0004-8695-9243
Emma E FurthDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA.
Gavyn Chern Wei BeeDivision of Gastroenterology and Hepatology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-6113-3312
Daniel L AldridgeInstitute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA.ORCID 0000-0003-2224-5159
Juliana DiamantinoDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia; Philadelphia, PA, USA.
Christopher A HunterInstitute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA.ORCID 0000-0003-3092-1428
Ken CadwellInstitute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA.ORCID 0000-0002-5860-0661
David M AronoffDivision of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0003-4587-6121
Joseph P ZackularDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA, USA.ORCID 0000-0002-3228-3055

Funding

Project 3: Defining adaptive immune interactions that shape Clostridioides difficile infectionU19AI174998 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI DREW WEISSMAN · 2023 to 2026
$7.6M
Immunity to CryptosporidiumR01AI148249 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHRISTOPHER A HUNTER, BORIS STRIEPEN · 2020 to 2026
$5.3M
Defining the role of enterococci in reshaping Clostridioides difficile infectionR01AI187174 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI Boone M. Prentice, Joseph Paul Zackular · 2025 to 2026
$1.6M
NIAID NIH HHS R01 AI148249NIAID NIH HHS R01 AI187174NIAID NIH HHS U19 AI174998
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41278677
PMCPMC12636620

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.