In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Katherine C LetaiDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0002-5516-3910 Bianca N IslamDepartment of Medicine, Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0002-2124-1028 Paola MenghiniDepartment of Medicine, Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0002-8779-088X Carlo De SalvoDepartment of Surgery, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0002-1523-1915 Neha S KhandekarDepartment of Medicine, Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0009-0004-9244-5070 Bruce W ArmstrongDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0009-0001-5276-493X Alka TomarDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0009-0002-7813-2268 Kim CurryDepartment of Surgery, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0009-0006-8703-620X Theresa T PizarroDepartment of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0003-3163-915X Paul J TesarDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0003-1532-3155 Marissa A ScavuzzoDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0003-0651-6369 Fabio CominelliDepartment of Medicine, Digestive Health Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0002-1571-1548 Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4MThe Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Fabio Cominelli · 2015 to 2026
$15.6MModulating Glial Fate and Function in Development and DiseaseR35NS116842 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI Paul Joseph Tesar · 2020 to 2026
$5.3MMedical Scientist Training Program at Case Western Reserve UniversityT32GM152319 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Heather Broihier, Alex Yee-Chen Huang · 2024 to 2026
$5.1MCYTOKINES AND INFLAMMATORY BOWEL DISEASER01DK042191 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO, PIZARRO, THERESA TORRES · 1995 to 2022
$4.7MCombined Training Program in Digestive Disease SciencesT32DK083251 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI COMINELLI, FABIO, FIOCCHI, CLAUDIO · 2010 to 2025
$3.6MThe role of gene enhancer elements in colon cancerR01CA160356 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI TESAR, PAUL JOSEPH · 2012 to 2023
$3.6MNCI NIH HHS R01 CA160356NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK042191NIDDK NIH HHS T32 DK083251NIGMS NIH HHS T32 GM007250NIGMS NIH HHS T32 GM152319NINDS NIH HHS R35 NS116842
6 · The paper itselfAbstract
Background and Aims: Inflammatory bowel disease is characterized by progressive epithelial, immune, and stromal dysfunction. Human datasets yield important insights yet are inherently descriptive, requiring animal models for Methods: We performed whole-ileum snRNA-seq on SAMP ( Results: We observed a primary type 2 immune phenotype in SAMP compared to AKR mice, but most transcriptional changes occurred in stromal and epithelial, not immune, cells. Stromal remodeling included increased fibroblast-derived Conclusion: This atlas of ileitis-prone SAMP mice provides a high-resolution resource for dissecting conserved and novel mechanisms of inflammation and tissue remodeling. Herein, we uncover disease-associated transcriptional changes conserved in human CD, presenting a translational platform for future mechanistic and therapeutic studies.
Identifiers
PMID41278662
PMCPMC12637558
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