Evidence map›Paper›PMID 41278658›Full record

ArticlebioRxiv : the preprint server for biology2025

Genetic elements promote retention of extrachromosomal DNA in cancer cells.

Venkat Sankar, King L Hung, Aditi Gnanasekar, Ivy Tsz-Lo Wong, Quanming Shi, Katerina Kraft, Matthew G Jones, Britney Jiayu He, Xiaowei Yan, Julia A Belk and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Venkat SankarDepartments of Dermatology and Genetics, Stanford University, Stanford, CA, USA.
King L HungDepartments of Dermatology and Genetics, Stanford University, Stanford, CA, USA.
Aditi GnanasekarSarafan ChEM-H, Stanford University, Stanford, CA, USA.
Ivy Tsz-Lo WongSarafan ChEM-H, Stanford University, Stanford, CA, USA.
Quanming ShiDepartments of Dermatology and Genetics, Stanford University, Stanford, CA, USA.
Katerina KraftDepartments of Dermatology and Genetics, Stanford University, Stanford, CA, USA.
Matthew G JonesDepartments of Dermatology and Genetics, Stanford University, Stanford, CA, USA.
Britney Jiayu HeDepartments of Dermatology and Genetics, Stanford University, Stanford, CA, USA.
Xiaowei YanDepartments of Dermatology and Genetics, Stanford University, Stanford, CA, USA.
Julia A BelkDepartments of Dermatology and Genetics, Stanford University, Stanford, CA, USA.
Kevin J LiuProgram in Cancer Biology, Stanford University, Stanford, CA, USA.
Sangya AgarwalDepartments of Dermatology and Genetics, Stanford University, Stanford, CA, USA.
Sean K WangDepartments of Dermatology and Genetics, Stanford University, Stanford, CA, USA.
Anton G HenssenDepartment of Pediatric Hematology and Oncology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Paul S MischelSarafan ChEM-H, Stanford University, Stanford, CA, USA.
Howard Y ChangDepartments of Dermatology and Genetics, Stanford University, Stanford, CA, USA.

Funding

Quantitative modeling of extrachromosomal DNA (ecDNA) evolution in tumorsK99CA286968 · NCI · STANFORD UNIVERSITY · PI JONES, MATTHEW GREGORY · 2024 to 2025
$335k
Amplifications and signaling of oncoproteins in cancerK00CA274692 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI HUNG, KING L. · 2025 to 2025
$96k
Regulation and retention of extrachromosomal oncogene amplifications in cancerF99CA274692 · NCI · STANFORD UNIVERSITY · PI HUNG, KING L. · 2022 to 2023
$82k
NCI NIH HHS F99 CA274692NCI NIH HHS K00 CA274692NCI NIH HHS K99 CA286968
6 · The paper itself

Abstract

Extrachromosomal DNA (ecDNA) is a prevalent and devastating form of oncogene amplification in cancer

Identifiers

PMID41278658
PMCPMC12632332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.