Evidence map›Paper›PMID 41278626›Full record

ArticlebioRxiv : the preprint server for biology2025

De novo protein design enables targeting of intractable oncogenic interfaces.

Varshika Ram Prakash, Yusuf Najy, Kalel Garrett, Brian F P Edwards, Benjamin L Kidder

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Varshika Ram PrakashDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
Yusuf NajyDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
Kalel GarrettDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
Brian F P EdwardsDepartment of Biochemistry, Microbiology and Immunology, Wayne State University, Detroit, MI, USA.
Benjamin L KidderDepartment of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.

Funding

Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI PAUL M STEMMER · 1985 to 2026
$68.4M
NCI NIH HHS P30 CA022453
6 · The paper itself

Abstract

Protein-protein interactions (PPIs) involving oncogenic drivers remain among the most intractable targets in cancer biology due to their dynamic conformations and limited accessibility to conventional small molecules. Although antibodies and indirect inhibitors have achieved clinical success against targets such as PD-1/PD-L1 and MYC, challenges persist related to tissue penetration, intracellular delivery, resistance, and incomplete blockade of key interface hotspots. Here, we present DesignForge, an integrated

Indexed as

binder designcontact mapsde novo protein designimmuno-oncologyMOE surface mappingoncogenic driversprotein-protein interactions

Identifiers

PMID41278626
PMCPMC12633288

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.